F11 monoclonal antibody
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Specification
Product Description
Mouse monoclonal antibody raised against native F11.
Immunogen
Native purified Human F11.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes human factor XI, 125I-factor XI, human factor XIa, BEGRck-factor XIa. It will inhibits clotting.
Form
Liquid
Isotype
IgG
Recommend Usage
Western Blot (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
Radioimmunoassay
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Gene Info — F11
Entrez GeneID
2160Gene Name
F11
Gene Alias
FXI, MGC141891
Gene Description
coagulation factor XI
Omim ID
264900Gene Ontology
HyperlinkGene Summary
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. [provided by RefSeq
Other Designations
plasma thromboplastin antecedent|platelet coagulation factor XI
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Interactome
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Pathway
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