F7 monoclonal antibody
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Specification
Product Description
Mouse monoclonal antibody raised against native F7.
Immunogen
Native purified Human F7.
Host
Mouse
Reactivity
Human
Specificity
This antibody recognizes human factor VII, factor VIIa, BFPRck factor VIIa.
Form
Liquid
Isotype
IgG1
Recommend Usage
Western Blot (5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Enzyme-linked Immunoabsorbent Assay
Radioimmunoassay
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Gene Info — F7
Entrez GeneID
2155Gene Name
F7
Gene Alias
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Gene Description
coagulation factor VII (serum prothrombin conversion accelerator)
Omim ID
227500Gene Ontology
HyperlinkGene Summary
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy. [provided by RefSeq
Other Designations
FVII coagulation protein|OTTHUMP00000018733|OTTHUMP00000018734|coagulation factor VII|eptacog alfa
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Interactome
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