IHC analysis of TLR2 in paraffin-embedded human spleen tissue. Using TLR2 monoclonal antibody, clone 1030A5.138 (Cat # MAB0066) at 1 : 100 (left) and isotype control (right) .
Intracellular flow analysis of TLR2 in 106 THP-1 cells. Using 5 uL of TLR2 monoclonal antibody, clone 1030A5.138 (Cat # MAB0066). The shaded histogram represents ThP-1 cells with no antibody present; Green represents isotype control ; red represents TLR2 antibody.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq