NR3C1 (Human) Cell-Based ELISA Kit
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Specification
Product Description
NR3C1 (Human) Cell-Based ELISA Kit is an indirect enzyme-linked immunoassay for qualitative determination of NR3C1 expression in cultured cells.
Suitable Sample
Attached Cell, Loosely Attached Cell, Suspension Cell
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Qualitative
Reactivity
Human, Mouse, Rat
Regulation Status
For research use only (RUO)
Storage Instruction
Store the kit at 4°C.
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Applications
Qualitative
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Gene Info — NR3C1
Entrez GeneID
2908Protein Accession#
P04150Gene Name
NR3C1
Gene Alias
GCCR, GCR, GR, GRL
Gene Description
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Omim ID
138040Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for glucocorticoids that can act as both a transcription factor and as a regulator of other transcription factors. This protein can also be found in heteromeric cytoplasmic complexes along with heat shock factors and immunophilins. The protein is typically found in the cytoplasm until it binds a ligand, which induces transport into the nucleus. Mutations in this gene are a cause of glucocorticoid resistance, or cortisol, resistance. Alternate splicing, the use of at least three different promoters, and alternate translation initiation sites result in several transcript variants encoding the same protein or different isoforms, but the full-length nature of some variants has not been determined. [provided by RefSeq
Other Designations
nuclear receptor subfamily 3, group C, member 1
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Interactome
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Pathway
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Disease
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Publication Reference
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Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis.
Hoepner R, Bagnoud M, Pistor M, Salmen A, Briner M, Synn H, Schrewe L, Guse K, Ahmadi F, Demir S, Laverick L, Gresle M, Worley P, Reichardt HM, Butzkueven H, Gold R, Metz I, Lühder F, Chan A.
Acta Neuropathologica 2019 Apr; [Epub].
Application:Quant, Human, Human T cells.
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Ursocholanic acid rescues mitochondrial function in common forms of familial Parkinson's disease.
Mortiboys H, Aasly J, Bandmann O.
Brain 2013 Oct; 136(Pt 10):3038.
Application:ELISA, Human, Human fibrobloast.
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Vitamin D increases glucocorticoid efficacy via inhibition of mTORC1 in experimental models of multiple sclerosis.
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