PDGFB (Human) ELISA Kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human PDGFB.
Limit of Detection:
Quality Control Testing:
The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed. Column A represents Assay Diluent A and column B represents Assay Diluent B.
Store the kit at -20°C. Standard should be stored at -20°C or -80°C. Avoid repeated freezing and thawing.
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq
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