F12 (Human) ELISA Kit
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Specification
Product Description
F12 (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human F12.
Suitable Sample
Cell Culture Supernatant, Milk, Plasma, Serum, Urine, CSF
Sample Volume
50 uL
Label
Peroxidase-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
0.024 to 100 ng/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store components of the kit at 4°C or -20°C as described in the protocol.
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Applications
Quantification
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Gene Info — F12
Entrez GeneID
2161Gene Name
F12
Gene Alias
HAE3, HAEX, HAF
Gene Description
coagulation factor XII (Hageman factor)
Gene Ontology
HyperlinkGene Summary
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq
Other Designations
Hageman factor|coagulation factor XII
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Interactome
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Pathway
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Disease
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Publication Reference
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Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation.
Maas C, Govers-Riemslag JW, Bouma B, Schiks B, Hazenberg BP, Lokhorst HM, Hammarstrom P, ten Cate H, de Groot PG, Bouma BN, Gebbink MF.
The Journal of Clinical Investigation 2008 Sep; 118(9):3208.
Application:Quant, Human, Plasma samples from patients with systemic amyloidosis.
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The elusive physiologic role of Factor XII.
Schmaier AH.
The Journal of Clinical Investigation 2008 Sep; 118(9):3006.
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Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment.
Stoll G, Kleinschnitz C, Nieswandt B.
Blood 2008 Nov; 112(9):3555.
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Misfolded proteins activate factor XII in humans, leading to kallikrein formation without initiating coagulation.
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