F7 (Human) Chromogenic Activity Assay Kit
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Specification
Product Description
F7 (Human) Chromogenic Activity Assay Kit is developed to determine human F7 activity in plasma and cell culture supernatants.
Suitable Sample
Cell Culture Supernatant, Plasma, Serum
Calibration Range
12.5 to 200 mIU/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Quality Control Testing
Standard curve
The standard curve is for the purpose of illustration only and should not be used to calculate unknowns. A standard curve should be generated each time the assay is performed.
Storage Instruction
Store the kit at -20°C. Store the Standard, FX, rhTF and FXa Substrate at -20°C. Store other components at 4°C.
Avoid repeated freezing and thawing. -
Applications
Functional Study
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Gene Info — F7
Entrez GeneID
2155Gene Name
F7
Gene Alias
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Gene Description
coagulation factor VII (serum prothrombin conversion accelerator)
Omim ID
227500Gene Ontology
HyperlinkGene Summary
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Alternative splicing of this gene results in 2 transcripts. Defects in this gene can cause coagulopathy. [provided by RefSeq
Other Designations
FVII coagulation protein|OTTHUMP00000018733|OTTHUMP00000018734|coagulation factor VII|eptacog alfa
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Interactome
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Pathway
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Publication Reference
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Successful synthesis of active human coagulation factor VII by co-expression of mammalian gamma-glutamyl carboxylase and modification of vit.K cycle in Drosophila Schneider S2 cells.
Nagahashi K, Umemura K, Kanayama N, Iwaki T.
Cytotechnology 2017 Apr; 69(2):317.
Application:Quant, Human, S2 cells.
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Successful synthesis of active human coagulation factor VII by co-expression of mammalian gamma-glutamyl carboxylase and modification of vit.K cycle in Drosophila Schneider S2 cells.
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