CTSB (Human) ELISA Kit
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Specification
Product Description
CTSB (Human) ELISA Kit is a sandwich enzyme immunoassay for the quantitative measurement of human CTSB.
Suitable Sample
Cell Culture Supernatant, Cell Lysates, Plasma (EDTA, heparin) and Serum
Sample Volume
100 uL
Label
HRP-conjugated
Detection Method
Colorimetric
Assay Type
Quantitative
Calibration Range
156 to 10000 pg/mL
Reactivity
Human
Regulation Status
For research use only (RUO)
Storage Instruction
Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles.
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Applications
Quantification
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Gene Info — CTSB
Entrez GeneID
1508Gene Name
CTSB
Gene Alias
APPS, CPSB
Gene Description
cathepsin B
Omim ID
116810Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
APP secretase|OTTHUMP00000116009|amyloid precursor protein secretase|cathepsin B1|cysteine protease|preprocathepsin B
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Interactome
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Disease
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Publication Reference
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Modulation of Cystatin F in Human Macrophages Impacts Cathepsin-Driven Killing of Multidrug-Resistant Mycobacterium tuberculosis.
Manoj Mandal, David Pires, Maria João Catalão, José Miguel Azevedo-Pereira, Elsa Anes.
Microorganisms 2023 Jul; 11(7):1861.
Application:ELISA, Human, Human monocyte-derived macrophages.
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Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.
Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L.
Neuron 2006 Sep; 51(6).
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Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene.
Cao L, Taggart RT, Berquin IM, Moin K, Fong D, Sloane BF.
Gene 1994 Feb; 139(2):163.
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Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs.
Chan SJ, San Segundo B, McCormick MB, Steiner DF.
PNAS 1986 Oct; 83(20):7721.
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Modulation of Cystatin F in Human Macrophages Impacts Cathepsin-Driven Killing of Multidrug-Resistant Mycobacterium tuberculosis.
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