The protein encoded by this gene is an NADPH-dependent retinal reductase whose highest activity is toward 9-cis and all-trans-retinol. The encoded enzyme also plays a role in the metabolism of short-chain aldehydes but does not exhibit steroid dehydrogenase activity. Defects in this gene are a cause of Leber congenital amaurosis type 3 (LCA3). [provided by RefSeq
Other Designations:
retinol dehydrogenase 12,retinol dehydrogenase 12, all-trans and 9-cis,short chain dehydrogenase/reductase family 7C, member 2