TRIM8 MaxPab mouse polyclonal antibody (B01)
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More Files
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Western Blot (Cell lysate)
TRIM8 MaxPab polyclonal antibody. Western Blot analysis of TRIM8 expression in HepG2.
Western Blot (Transfected lysate)
Western Blot analysis of TRIM8 expression in transfected 293T cell line (H00081603-T01) by TRIM8 MaxPab polyclonal antibody.
Lane 1: TRIM8 transfected lysate(60.61 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human TRIM8 protein.
Immunogen
TRIM8 (AAH21925.1, 1 a.a. ~ 551 a.a) full-length human protein.
Sequence
MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAYNQKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGHSVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLVEEKVNQLKEEVRLQYEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTEDVSFMKNTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTPVPFLQSVPLYPCGVSSSGAEKRKHSTAFPEASFLETSSGPVGGQYGAAGTASGEGQSGQPLGPCSSTQHLVALPGGAQPVHSSPVFPPSQYPNGSAAQQPMLPQYGGRKILVCSVDNCYCSSVANHGGHQPYPRSGHFPWTVPSQEYSHPLPPTPSVPQSLPSLAVRDWLDASQQPGHQDFYRVYGQPSTKHYVTS
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (97); Rat (97)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Note
For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
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Applications
Western Blot (Cell lysate)
TRIM8 MaxPab polyclonal antibody. Western Blot analysis of TRIM8 expression in HepG2.Western Blot (Transfected lysate)
Western Blot analysis of TRIM8 expression in transfected 293T cell line (H00081603-T01) by TRIM8 MaxPab polyclonal antibody.
Lane 1: TRIM8 transfected lysate(60.61 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — TRIM8
Entrez GeneID
81603GeneBank Accession#
BC021925.1Protein Accession#
AAH21925.1Gene Name
TRIM8
Gene Alias
GERP, RNF27
Gene Description
tripartite motif-containing 8
Omim ID
606125Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes. [provided by RefSeq
Other Designations
glioblastoma expressed ring finger protein|ring finger protein 27|tripartite motif protein TRIM8
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Interactome
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Disease
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Publication Reference
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TRIM8 regulates Nanog via Hsp90beta-mediated nuclear translocation of STAT3 in embryonic stem cells.
Okumura F, Okumura AJ, Matsumoto M, Nakayama KI, Hatakeyama S.
Biochim Biophys Acta 2011 Jun; 13:1784.
Application：IP-WB, WB-Ce, WB-Tr, Mouse, E14, ES cells.
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TRIM8 modulates STAT3 activity through negative regulation of PIAS3.
Okumura F, Matsunaga Y, Katayama Y, Nakayama KI, Hatakeyama S.
Journal of Cell Science 2010 Jul; 123(Pt 13):2238.
Application：WB-Ce, Human, Mouse, HEK 293T, NIH/3T3 cells.
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TRIM8 regulates Nanog via Hsp90beta-mediated nuclear translocation of STAT3 in embryonic stem cells.
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