CFHR5 purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
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Western Blot (Transfected lysate)
Western Blot analysis of CFHR5 expression in transfected 293T cell line (H00081494-T02) by CFHR5 MaxPab polyclonal antibody.
Lane 1: CFHR5 transfected lysate(64.40 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human CFHR5 protein.
Immunogen
CFHR5 (NP_110414.1, 1 a.a. ~ 569 a.a) full-length human protein.
Sequence
MLLLFSVILISWVSTVGGEGTLCDFPKIHHGFLYDEEDYNPFSQVPTGEVFYYSCEYNFVSPSKSFWTRITCTEEGWSPTPKCLRMCSFPFVKNGHSESSGLIHLEGDTVQIICNTGYSLQNNEKNISCVERGWSTPPICSFTKGECHVPILEANVDAQPKKESYKVGDVLKFSCRKNLIRVGSDSVQCYQFGWSPNFPTCKGQVRSCGPPPQLSNGEVKEIRKEEYGHNEVVEYDCNPNFIINGPKKIQCVDGEWTTLPTCVEQVKTCGYIPELEYGYVQPSVPPYQHGVSVEVNCRNEYAMIGNNMITCINGIWTELPMCVATHQLKRCKIAGVNIKTLLKLSGKEFNHNSRIRYRCSDIFRYRHSVCINGKWNPEVDCTEKREQFCPPPPQIPNAQNMTTTVNYQDGEKVAVLCKENYLLPEAKEIVCKDGRWQSLPRCVESTAYCGPPPSINNGDTTSFPLSVYPPGSTVTYRCQSFYKLQGSVTVTCRNKQWSEPPRCLDPCVVSEENMNKNNIQLKWRNDGKLYAKTGDAVEFQCKFPHKAMISSPPFRAICQEGKFEYPICE
Host
Rabbit
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of CFHR5 expression in transfected 293T cell line (H00081494-T02) by CFHR5 MaxPab polyclonal antibody.
Lane 1: CFHR5 transfected lysate(64.40 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — CFHR5
Entrez GeneID
81494GeneBank Accession#
NM_030787Protein Accession#
NP_110414.1Gene Name
CFHR5
Gene Alias
CFHL5, FHR-5, FHR5, FLJ10549, MGC133240
Gene Description
complement factor H-related 5
Omim ID
608593Gene Ontology
HyperlinkOther Designations
factor H-related protein 5
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Interactome
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Disease
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Publication Reference
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A Family Affair: Addressing the Challenges of Factor H and the Related Proteins.
Felix Poppelaars, Elena Goicoechea de Jorge, Ilse Jongerius, Antje J Baeumner, Mark-Steven Steiner, Mihály Józsi, Erik J M Toonen, Diana Pauly, SciFiMed consortium.
Frontiers in Immunology 2021 Mar; 12:660194.
Application：ELISA, IHC, Human, Human kidney.
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Gain-of-function factor H-related 5 protein impairs glomerular complement regulation resulting in kidney damage.
Talat H Malik, Daniel P Gitterman, Deborah P Lavin, Hannah J Lomax-Browne, E Christina Hiemeyer, Linda B Moran, Katharina Boroviak, H Terence Cook, Alyssa C Gilmore, Mawj Mandwie, Amina Ahmad, Ian E Alexander, Grant J Logan, Kevin J Marchbank, Allan Bradley, Matthew C Pickering.
PNAS 2021 Mar; 118(13):e202272211.
Application：Cap Ab, ELISA, IF, Mouse, Mouse kidney, Mouse plasma.
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Glomerular complement factor H related protein 5 (FHR5) is highly prevalent in C3 glomerulopathy and associated with renal impairment.
Medjeral-Thomas NR, Moffitt H, Lomax-Browne HJ, Constantinou N, Cairns T, Cook HT, Pickering MC.
Kidney International Reports 2019 Jun; 4(10):1387.
Application：IF, IHC-P, Human, Human kidney.
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Circulating complement factor H-related protein 5 levels contribute to development and progression of IgA nephropathy.
Zhu L, Guo WY, Shi SF, Liu LJ, Lv JC, Medjeral-Thomas NR, Lomax-Browne HJ, Pickering MC, Zhang H.
Kidney International 2018 Jul; 94(1):150.
Application：ELISA, Human, Plasma.
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Rapid isolation of pure Complement Factor H from serum for functional studies by the use of a monoclonal antibody that discriminates FH from all the other isoforms.
Berra S, Clivio A.
Molecular Immunology 2016 Apr; 72:65.
Application：WB, Human, Serum.
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A novel CFHR5 fusion protein causes C3 glomerulopathy in a family without Cypriot ancestry.
Medjeral-Thomas N, Malik TH, Patel MP, Toth T, Terence Cook H, Tomson C, Pickering MC.
Kidney International 2014 Apr; 85(4):933.
Application：WB, Human, Serum.
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A Family Affair: Addressing the Challenges of Factor H and the Related Proteins.
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