PNPO polyclonal antibody (A01)
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More Files
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Western Blot (Cell lysate)
PNPO polyclonal antibody (A01), Lot # 060529JCS1 Western Blot analysis of PNPO expression in MES-SA/Dx5 ( Cat # L021V1 ).
Western Blot detection against Immunogen (37 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a partial recombinant PNPO.
Immunogen
PNPO (NP_060599, 163 a.a. ~ 261 a.a) partial recombinant protein with GST tag.
Sequence
KSSQIGAVVSHQSSVIPDREYLRKKNEELEQLYQDQEVPKPKSWGGYVLYPQVMEFWQGQTNRLHDRIVFRRGLPTGDSPLGPMTHRGEEDWLYERLAP
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (90); Rat (89)
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (37 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
PNPO polyclonal antibody (A01), Lot # 060529JCS1 Western Blot analysis of PNPO expression in MES-SA/Dx5 ( Cat # L021V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — PNPO
Entrez GeneID
55163GeneBank Accession#
NM_018129Protein Accession#
NP_060599Gene Name
PNPO
Gene Alias
FLJ10535, PDXPO
Gene Description
pyridoxamine 5'-phosphate oxidase
Gene Ontology
HyperlinkGene Summary
The enzyme encoded by this gene catalyzes the terminal, rate-limiting step in the synthesis of pyridoxal 5'-phosphate, also known as vitamin B6. Vitamin B6 is a required co-factor for enzymes involved in both homocysteine metabolism and synthesis of neurotransmitters such as catecholamine. Mutations in this gene result in pyridoxamine 5'-phosphate oxidase (PNPO) deficiency, a form of neonatal epileptic encephalopathy. [provided by RefSeq
Other Designations
pyridoxal 5'-phosphate synthase|pyridoxine 5'-phosphate oxidase
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Interactome
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Pathway
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Disease
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Publication Reference
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Toxicological biomarkers of 2,3,4,7,8-pentachlorodibenzofuran in proteins secreted by HepG2 cells.
Phark S, Park SY, Choi S, Zheng Z, Cho E, Lee M, Lim JY, Seo JB, Won NH, Jung WW, Sul D.
Biochimica et Biophysica Acta 2012 Apr; 1824(4):656.
Application：WB, Human, HepG2 cells.
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PNPO deficiency: An under diagnosed inborn error of pyridoxine metabolism.
Khayat M, Korman SH, Frankel P, Weintraub Z, Hershckowitz S, Sheffer VF, Elisha MB, Wevers RA, Falik-Zaccai TC.
Molecular Genetics and Metabolism 2008 May; 94(4):431.
Application：WB-Tr, Human, CHO cells.
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Toxicological biomarkers of 2,3,4,7,8-pentachlorodibenzofuran in proteins secreted by HepG2 cells.
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