ERCC6L purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Cell lysate)
ERCC6L MaxPab polyclonal antibody. Western Blot analysis of ERCC6L expression in HeLa.
Western Blot (Transfected lysate)
Western Blot analysis of ERCC6L expression in transfected 293T cell line (H00054821-T01) by ERCC6L MaxPab polyclonal antibody.
Lane 1: ERCC6L transfected lysate(46.09 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human ERCC6L protein.
Immunogen
ERCC6L (AAH08808.1, 1 a.a. ~ 419 a.a) full-length human protein.
Sequence
MEKSFATKNEAVQKETLQEGPKQEALQEDPLESFNYVLSKSTKADIGPNLDQLKDDEILRHCNPWPIISITNESQNAESNVSIIEIADDLSASHSALQDAQASEAKLEEEPSASSPQYACDFNLFLEDSADNRQNFSSQSLEHVEKENSLCGSAPNSRAGFVHSKTCLSWEFSEKDDEPEEVVVKAKIRSKARRIVSDGEDEDDSFKDTSSINPFNTSLFQFSSVKQFDASTPKNDISPPGRFFSSQIPSSVNKSMNSRRSLASRRSLINMVLDHVEDMEERLDDSSEAKGPEDYPEEGVEESSGEASKYTEEDPSGETLSSENKSSWLMTSKPSALAQETSLGAPEPLSGEQLVGSPQDKAAEATNDYETLVKRGKELKECGKIQEALNCLVKALDIKSADPEVMLLTLSLYKQLNNN
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (60); Rat (60)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
ERCC6L MaxPab polyclonal antibody. Western Blot analysis of ERCC6L expression in HeLa.Western Blot (Transfected lysate)
Western Blot analysis of ERCC6L expression in transfected 293T cell line (H00054821-T01) by ERCC6L MaxPab polyclonal antibody.
Lane 1: ERCC6L transfected lysate(46.09 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — ERCC6L
Entrez GeneID
54821GeneBank Accession#
BC008808.2Protein Accession#
AAH08808.1Gene Name
ERCC6L
Gene Alias
FLJ20105, MGC131695, PICH
Gene Description
excision repair cross-complementing rodent repair deficiency, complementation group 6-like
Gene Ontology
HyperlinkGene Summary
O
Other Designations
Plk1-interacting checkpoint helicase|SNF2/RAD54 family protein|excision repair cross-complementing rodent repair deficiency complementation group 6 - like|excision repair protein ERCC6-like
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Interactome
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Publication Reference
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An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress.
Taichi Igarashi, Marianne Mazevet, Takaaki Yasuhara, Kimiyoshi Yano, Akifumi Mochizuki, Makoto Nishino, Tatsuya Yoshida, Yukihiro Yoshida, Nobuhiko Takamatsu, Akihide Yoshimi, Kouya Shiraishi, Hidehito Horinouchi, Takashi Kohno, Ryuji Hamamoto, Jun Adachi, Lee Zou, Bunsyo Shiotani.
Nature Communications 2023 Aug; 14(1):4991.
Application：IF, Human, N/A.
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FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics.
Colin Stok, Stavroula Tsaridou, Nathalie van den Tempel, Marieke Everts, Elles Wierenga, Femke J Bakker, Yannick Kok, Inês Teles Alves, Lucas T Jae, Maximilian W D Raas, Pim J Huis In 't Veld, H Rudolf de Boer, Arkajyoti Bhattacharya, Eleftheria Karanika, Harry Warner, Mengting Chen, Bert van de Kooij, Julien Dessapt, Lars Ter Morsche, Polina Perepelkina, Amelie Fradet-Turcotte, Victor Guryev, Eelco C Tromer, Kok-Lung Chan, Rudolf S N Fehrmann, Marcel A T M van Vugt.
Cell Reports 2023 Jun; 42(7):112668.
Application：IF, Human, HAP1 cells.
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Mus81-Eme1-dependent aberrant processing of DNA replication intermediates in mitosis impairs genome integrity.
Nicolás Luis Calzetta, Marina Alejandra González Besteiro, Vanesa Gottifredi.
Science Advances 2020 Dec; 6(50):eabc8257.
Application：IF, Human, U-2 OS cells.
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Distinct Roles for Condensin's Two ATPase Sites in Chromosome Condensation.
Elbatsh AMO, Kim E, Eeftens JM, Raaijmakers JA, van der Weide RH, García-Nieto A, Bravo S, Ganji M, Uit de Bos J, Teunissen H, Medema RH, de Wit E, Haering CH, Dekker C, Rowland BD.
Molecular Cell 2019 Dec; 76(5):724.
Application：IF, Human, HAP1 cells.
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53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process.
Tiwari A, Addis Jones O, Chan KL.
Nature Communications 2018 Feb; 9:677.
Application：IF, Human, HeLa, U2OS, Saos-2 Cells.
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CTCF driven TERRA transcription facilitates completion of telomere DNA replication.
Beishline K, Vladimirova O, Tutton S, Wang Z, Deng Z, Lieberman PM.
Nature Communications 2017 Dec; 8(1):2114.
Application：IF, Human, HCT-116 cells.
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Elevated levels of TRF2 induce telomeric ultrafine anaphase bridges and rapid telomere deletions.
Nera B, Huang HS, Lai T, Xu L.
Nature Communications 2015 Dec; 6:10132.
Application：IF, Human, HT1080 cells.
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An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress.
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