NCSTN purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
NCSTN MaxPab rabbit polyclonal antibody. Western Blot analysis of NCSTN expression in mouse lung.
Western Blot (Transfected lysate)
Western Blot analysis of NCSTN expression in transfected 293T cell line (H00023385-T02) by NCSTN MaxPab polyclonal antibody.
Lane 1: NCSTN transfected lysate(76.70 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human NCSTN protein.
Immunogen
NCSTN (AAH47621.1, 1 a.a. ~ 689 a.a) full-length human protein.
Sequence
MDFNLILESLCRGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEEDLQWVLTDGPNPPYMVLLESKHFTRDLMEKLKGRTSRIAGLAVSLTKPSPASGFSPSVQCPNDGFGVYSNSYGPEFAHCREIQWNSLGNGLAYEDFSFPIFLLEDENETKVIKQCYQDHNLSQNGSAPTFPLCAMQLFSHMHAVISTATCMRRSSIQSTFSINPEIVCDPLSDYNVWSMLKPINTTGTLKPDDRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALQKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMEKGKFPVQLENVDSFVELGQVALRTSLELWMHTDPVSQKNESVRNQVEDLLATLEKSGAGVPAVILRRPNQSQPLPPSSLQRFLRARNISGVVLADHSGAFHNKYYQSIYDTAENINVSYPEWLSPEEDLNFVTDTAKALADVATVLGRALYELAGGTNFSDTVQADPQTVTRLLYGFLIKANNSWFQSILRQDLRSYLGDGPLQHYIAVSSPTNTTYVVQYALANLTGTVVNLTREQCQDPSKVPSENKDLYEYSWVQGPLHSNETDRLPRCVRSTARLARALSPAFELSQWSSTEYSTWTESRWKDIHARIFLIASKELELITLTVGFGILIFSLIVTYCINAKADVLFIAPREPGAVSY
Host
Rabbit
Reactivity
Human, Mouse
Interspecies Antigen Sequence
Mouse (88); Rat (88)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
NCSTN MaxPab rabbit polyclonal antibody. Western Blot analysis of NCSTN expression in mouse lung.Western Blot (Transfected lysate)
Western Blot analysis of NCSTN expression in transfected 293T cell line (H00023385-T02) by NCSTN MaxPab polyclonal antibody.
Lane 1: NCSTN transfected lysate(76.70 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — NCSTN
Entrez GeneID
23385GeneBank Accession#
BC047621Protein Accession#
AAH47621.1Gene Name
NCSTN
Gene Alias
APH2, KIAA0253
Gene Description
nicastrin
Omim ID
605254Gene Ontology
HyperlinkGene Summary
This gene encodes a Type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Alternatively spliced transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq
Other Designations
ATAG1874|OTTHUMP00000031839|anterior pharynx-defective 2
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Interactome
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Pathway
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Disease
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