DUSP14 purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of DUSP14 expression in transfected 293T cell line (H00011072-T02) by DUSP14 MaxPab polyclonal antibody.
Lane 1: DUSP14 transfected lysate(22.30 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human DUSP14 protein.
Immunogen
DUSP14 (NP_008957.1, 1 a.a. ~ 198 a.a) full-length human protein.
Sequence
MSSRGHSTLPRTLMAPRMISEGDIGGIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKMVQTPYGIVPDVYEKESRHLMPYWGI
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Mouse (93); Rat (94)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of DUSP14 expression in transfected 293T cell line (H00011072-T02) by DUSP14 MaxPab polyclonal antibody.
Lane 1: DUSP14 transfected lysate(22.30 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — DUSP14
Entrez GeneID
11072GeneBank Accession#
NM_007026.1Protein Accession#
NP_008957.1Gene Name
DUSP14
Gene Alias
MKP-L, MKP6
Gene Description
dual specificity phosphatase 14
Omim ID
606618Gene Ontology
HyperlinkGene Summary
In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80; MIM 112203) and B7-2 (CD86; MIM 601020) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 (IL2; MIM 147680) and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK (e.g., MAP2K4; MIM 601335) and JNK (see MIM 601158), and the subsequent creation of AP1 transcription factor (see MIM 165160). DUSP14 is a negative regulator of CD28 signaling.[supplied by OMIM
Other Designations
MKP-1 like protein tyrosine phosphatase|OTTHUMP00000164064|OTTHUMP00000164065
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Interactome
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Pathway
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