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Enzyme-linked Immunoabsorbent Assay

Western Blot (Recombinant protein)

Antibody Production

Protein Array

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

AKAP12

Gene Alias

AKAP250, DKFZp686M0430, DKFZp686O0331, FLJ20945, FLJ97621

Gene Description

A kinase (PRKA) anchor protein 12

Omim ID

Gene Ontology

Gene Summary

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq

Other Designations

A kinase (PRKA) anchor protein (gravin) 12|A-kinase anchor protein, 250kDa|OTTHUMP00000017426|kinase scaffold protein gravin|myasthenia gravis autoantigen gravin