LONP1 purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
LONP1 MaxPab rabbit polyclonal antibody. Western Blot analysis of LONP1 expression in mouse kidney.
Western Blot (Tissue lysate)
LONP1 MaxPab rabbit polyclonal antibody. Western Blot analysis of LONP1 expression in human kidney.
Western Blot (Cell lysate)
LONP1 MaxPab rabbit polyclonal antibody. Western Blot analysis of LONP1 expression in HepG2.
Western Blot (Transfected lysate)
Western Blot analysis of LONP1 expression in transfected 293T cell line (H00009361-T02) by LONP1 MaxPab polyclonal antibody.
Lane 1: LONP1 transfected lysate(106.50 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to LONP1 on HeLa cell. [antibody concentration 10 ug/ml]
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human LONP1 protein.
Immunogen
LONP1 (NP_004784.2, 1 a.a. ~ 959 a.a) full-length human protein.
Sequence
MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGQRTCDASPPWALWGRGPAIGGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEGPVITALTPMTIPDVFPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVESLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSKRGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTIRDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLYKALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEKFRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDLARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARALNREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQGDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSGYVAQEKLAIAERYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVLRKSAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWTAMGGSTLFVETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFARAFLMQHAPANDYLVTSHIHLHVPEGATPKDGPSAGCTIVTALLSLAMGRPVRQNLAMTGEVSLTGKILPVGGIKEKTIAAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFVEHYREIFDIAFPDEQAEALAVER
Host
Rabbit
Reactivity
Human, Mouse
Interspecies Antigen Sequence
Mouse (87); Rat (88)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
LONP1 MaxPab rabbit polyclonal antibody. Western Blot analysis of LONP1 expression in mouse kidney.Western Blot (Tissue lysate)
LONP1 MaxPab rabbit polyclonal antibody. Western Blot analysis of LONP1 expression in human kidney.Western Blot (Cell lysate)
LONP1 MaxPab rabbit polyclonal antibody. Western Blot analysis of LONP1 expression in HepG2.Western Blot (Transfected lysate)
Western Blot analysis of LONP1 expression in transfected 293T cell line (H00009361-T02) by LONP1 MaxPab polyclonal antibody.
Lane 1: LONP1 transfected lysate(106.50 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to LONP1 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — LONP1
Entrez GeneID
9361GeneBank Accession#
NM_004793.2Protein Accession#
NP_004784.2Gene Name
LONP1
Gene Alias
LON, LONP, LonHS, MGC1498, PIM1, PRSS15, hLON
Gene Description
lon peptidase 1, mitochondrial
Omim ID
605490Gene Ontology
HyperlinkGene Summary
This gene encodes a mitochondrial matrix protein in the Lon family of ATP-dependent proteases. A similar E. coli protein regulates gene expression by targeting specific regulatory proteins for degradation. This protein binds a specific sequence in the light and heavy chain promoters of the mitochondrial genome which are involved in regulation of DNA replication and transcription. [provided by RefSeq
Other Designations
LON protease|Lon protease-like protein|hLON ATP-dependent protease|mitochondrial lon peptidase 1|protease, serine, 15
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Interactome
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Publication Reference
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Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness.
Lee YK, Lim JJ, Jeoun UW, Min S, Lee EB, Kwon SM, Lee C, Yoon G.
The Journal of Biological Chemistry 2017 Oct; 292(49):20208.
Application：WB-Ce, Human, SNU387 cells.
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Lactate-mediated mitoribosomal defects impair mitochondrial oxidative phosphorylation and promote hepatoma cell invasiveness.
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