EXO1 purified MaxPab mouse polyclonal antibody (B01P)
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human EXO1 protein.
Immunogen
EXO1 (NP_006018.3, 1 a.a. ~ 846 a.a) full-length human protein.
Sequence
MGIQGLLQFIKEASEPIHVRKYKGQVVAVDTYCWLHKGAIACAEKLAKGEPTDRYVGFCMKFVNMLLSHGIKPILVFDGCTLPSKKEVERSRRERRQANLLKGKQLLREGKVSEARECFTRSINITHAMAHKVIKAARSQGVDCLVAPYEADAQLAYLNKAGIVQAIITEDSDLLAFGCKKVILKMDQFGNGLEIDQARLGMCRQLGDVFTEEKFRYMCILSGCDYLSSLRGIGLAKACKVLRLANNPDIVKVIKKIGHYLKMNITVPEDYINGFIRANNTFLYQLVFDPIKRKLIPLNAYEDDVDPETLSYAGQYVDDSIALQIALGNKDINTFEQIDDYNPDTAMPAHSRSHSWDDKTCQKSANVSSIWHRNYSPRPESGTVSDAPQLKENPSTVGVERVISTKGLNLPRKSSIVKRPRSAELSEDDLLSQYSLSFTKKTKKNSSEGNKSLSFSEVFVPDLVNGPTNKKSVSTPPRTRNKFATFLQRKNEESGAVVVPGTRSRFFCSSDSTDCVSNKVSIQPLDETAVTDKENNLHESEYGDQEGKRLVDTDVARNSSDDIPNNHIPGDHIPDKATVFTDEESYSFESSKFTRTISPPTLGTLRSCFSWSGGLGDFSRTPSPSPSTALQQFRRKSDSPTSLPENNMSDVSQLKSEESSDDESHPLREGACSSQSQESGEFSLQSSNASKLSQCSSKDSDSEESDCNIKLLDSQSDQTSKLCLSHFSKKDTPLRNKVPGLYKSSSADSLSTTKIKPLGPARASGLSKKPASIQKRKHHNAENKPGLQIKLNELWKNFGFKKDSEKLPPCKKPLSPVRDNIQLTPEAEEDIFNKPECGRVQRAIFQ
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (72); Rat (75)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of EXO1 expression in transfected 293T cell line (H00009156-T01) by EXO1 MaxPab polyclonal antibody.
Lane 1: EXO1 transfected lysate(93.06 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to EXO1 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — EXO1
Entrez GeneID
9156GeneBank Accession#
NM_006027.3Protein Accession#
NP_006018.3Gene Name
EXO1
Gene Alias
HEX1, hExoI
Gene Description
exonuclease 1
Omim ID
606063Gene Ontology
HyperlinkGene Summary
This gene encodes a protein with 5' to 3' exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms. [provided by RefSeq
Other Designations
OTTHUMP00000037878|OTTHUMP00000037879|rad2 nuclease family member, homolog of S. cerevisiae exonuclease 1
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Interactome
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Pathway
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Publication Reference
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Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1.
Meta Volcic, Konstantin M J Sparrer, Lennart Koepke, Dominik Hotter, Daniel Sauter, Christina M Stürzel, Myriam Scherer, Thomas Stamminger, Thomas G Hofmann, Nathalie J Arhel, Lisa Wiesmüller, Frank Kirchhoff.
Nature Microbiology 2020 Oct; 5(10):1247.
Application:IF, Human, WTK1 cells.
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Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1.
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