PRPF4 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
PRPF4 MaxPab polyclonal antibody. Western Blot analysis of PRPF4 expression in human spleen.
Western Blot (Transfected lysate)
Western Blot analysis of PRPF4 expression in transfected 293T cell line by PRPF4 MaxPab polyclonal antibody.
Lane 1: PRPF4 transfected lysate(57.42 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to PRPF4 on HeLa cell. [antibody concentration 10 ug/ml]
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human PRPF4 protein.
Immunogen
PRPF4 (NP_004688, 1 a.a. ~ 522 a.a) full-length human protein.
Sequence
MASSRASSTQATKTKAPDDLVAPVVKKPHIYYGSLEEKERERLAKGESGILGKDGLKAGIEAGNINITSGEVFEIEEHISERQAEVLAEFERRKRARQINVSTDDSEVKACLRALGEPITLFGEGPAERRERLRNILSVVGTDALKKTKKDDEKSKKSKEEYQQTWYHEGPNSLKVARLWIANYSLPRAMKRLEEARLHKEIPETTRTSQMQELHKSLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (98); Rat (98)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
PRPF4 MaxPab polyclonal antibody. Western Blot analysis of PRPF4 expression in human spleen.Western Blot (Transfected lysate)
Western Blot analysis of PRPF4 expression in transfected 293T cell line by PRPF4 MaxPab polyclonal antibody.
Lane 1: PRPF4 transfected lysate(57.42 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to PRPF4 on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — PRPF4
Entrez GeneID
9128GeneBank Accession#
NM_004697Protein Accession#
NP_004688Gene Name
PRPF4
Gene Alias
HPRP4, HPRP4P, PRP4, Prp4p
Gene Description
PRP4 pre-mRNA processing factor 4 homolog (yeast)
Omim ID
607795Gene Ontology
HyperlinkGene Summary
The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM
Other Designations
OTTHUMP00000021947|PRP4 pre-mRNA processing factor 4 homolog|PRP4/STK/WD splicing factor|U4/U6 small nuclear ribonucleoprotein Prp4
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Interactome
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Publication Reference
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An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth.
Adler AS, McCleland ML, Yee S, Yaylaoglu M, Hussain S, Cosino E, Quinones G, Modrusan Z, Seshagiri S, Torres E, Chopra VS, Haley B, Zhang Z, Blackwood EM, Singh M, Junttila M, Stephan JP, Liu J, Pau G, Fearon ER, Jiang Z, Firestein R.
Genes & Development 2014 May; 28(10):1068.
Application：WB, Human, COLO 678, HCA-7, HT55, SW948, SK-CO-1, CL-40, DLD-1, SW620, LS1034, C2BBe1, RKO, KM-12, SW1463, HCT-15, SW1417, SW48, SW837 cells.
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PRPF mutations are associated with generalized defects in spliceosome formation and pre-mRNA splicing in patients with retinitis pigmentosa.
Tanackovic G, Ransijn A, Thibault P, Abou Elela S, Klinck R, Berson EL, Chabot B, Rivolta C.
Hum Mol Genet 2011 Mar; 20:2116.
Application：WB-Ce, Human, RP-PRPF lymphoblasts.
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An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth.
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