Products

Western Blot (Tissue lysate)

Western Blot (Transfected lysate)

Immunofluorescence

Entrez GeneID

GeneBank Accession#

Protein Accession#

Gene Name

NR1I2

Gene Alias

BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR

Gene Description

nuclear receptor subfamily 1, group I, member 2

Omim ID

Gene Ontology

Gene Summary

This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq

Other Designations

orphan nuclear receptor PXR|steroid and xenobiotic receptor