TNFSF10 purified MaxPab rabbit polyclonal antibody (D01P)
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human TNFSF10 protein.
Immunogen
TNFSF10 (AAH20220.1, 1 a.a. ~ 300 a.a) full-length human protein.
Sequence
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFRGLFSWLTDLERKSNNLKVTIQFSG
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Mouse (65)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
TNFSF10 MaxPab rabbit polyclonal antibody. Western Blot analysis of TNFSF10 expression in human liver.Western Blot (Transfected lysate)
Western Blot analysis of TNFSF10 expression in transfected 293T cell line (H00008743-T02) by TNFSF10 MaxPab polyclonal antibody.
Lane 1: TNFSF10 transfected lysate(34.90 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — TNFSF10
Entrez GeneID
8743GeneBank Accession#
BC020220Protein Accession#
AAH20220.1Gene Name
TNFSF10
Gene Alias
APO2L, Apo-2L, CD253, TL2, TRAIL
Gene Description
tumor necrosis factor (ligand) superfamily, member 10
Omim ID
603598Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. [provided by RefSeq
Other Designations
Apo-2 ligand|TNF-related apoptosis inducing ligand TRAIL|tumor necrosis factor (ligand) family, member 10|tumor necrosis factor apoptosis-inducing ligand splice variant delta
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Interactome
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Pathway
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Disease
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Publication Reference
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Long non-coding RNA CCAT1 is overexpressed in endometrial cancer and regulates growth and transcriptome of endometrial adenocarcinoma cells.
Treeck O, Skrzypczak M, Schüler-Toprak S, Weber F, Ortmann O.
The International Journal of Biochemistry & Cell Biology 2020 Mar; 122:105740.
Application:WB-Tr, Human, HEC-1A cells.
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Long non-coding RNA CCAT1 is overexpressed in endometrial cancer and regulates growth and transcriptome of endometrial adenocarcinoma cells.
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