PIAS1 (Human) Recombinant Protein (Q01)
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More Files
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Specification
Product Description
Human PIAS1 partial ORF ( NP_057250, 476 a.a. - 565 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
SAKRTCPSLSPTSPLNNKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDLQGLDFFPFLSGDNQHYNTSLLAAAA
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
35.64
Interspecies Antigen Sequence
Mouse (99)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — PIAS1
Entrez GeneID
8554GeneBank Accession#
NM_016166Protein Accession#
NP_057250Gene Name
PIAS1
Gene Alias
DDXBP1, GBP, GU/RH-II, MGC141878, MGC141879, ZMIZ3
Gene Description
protein inhibitor of activated STAT, 1
Omim ID
603566Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq
Other Designations
AR interacting protein|DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1|protein inhibitor of activated STAT-1|zinc finger, MIZ-type containing 3
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Interactome
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Pathway
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Disease
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