ALDH5A1 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
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Western Blot (Tissue lysate)
ALDH5A1 MaxPab polyclonal antibody. Western Blot analysis of ALDH5A1 expression in human liver.
Western Blot (Cell lysate)
ALDH5A1 MaxPab polyclonal antibody. Western Blot analysis of ALDH5A1 expression in K-562.
Western Blot (Transfected lysate)
Western Blot analysis of ALDH5A1 expression in transfected 293T cell line (H00007915-T01) by ALDH5A1 MaxPab polyclonal antibody.
Lane 1: ALDH5A1 transfected lysate(58.85 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human ALDH5A1 protein.
Immunogen
ALDH5A1 (NP_001071.1, 1 a.a. ~ 535 a.a) full-length human protein.
Sequence
MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAATFPVQDPASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYLELKYVCYGGL
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
ALDH5A1 MaxPab polyclonal antibody. Western Blot analysis of ALDH5A1 expression in human liver.Western Blot (Cell lysate)
ALDH5A1 MaxPab polyclonal antibody. Western Blot analysis of ALDH5A1 expression in K-562.Western Blot (Transfected lysate)
Western Blot analysis of ALDH5A1 expression in transfected 293T cell line (H00007915-T01) by ALDH5A1 MaxPab polyclonal antibody.
Lane 1: ALDH5A1 transfected lysate(58.85 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — ALDH5A1
Entrez GeneID
7915GeneBank Accession#
NM_001080.3Protein Accession#
NP_001071.1Gene Name
ALDH5A1
Gene Alias
SSADH, SSDH
Gene Description
aldehyde dehydrogenase 5 family, member A1
Gene Ontology
HyperlinkGene Summary
This protein belongs to the aldehyde dehydrogenase family of proteins. This gene encodes a mitochondrial NAD(+)-dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, is a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA). In response to the defect, physiologic fluids from patients accumulate GHB, a compound with numerous neuromodulatory properties. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq
Other Designations
NAD(+)-dependent succinic semialdehyde dehydrogenase|OTTHUMP00000016088|aldehyde dehydrogenase 5A1|mitochondrial succinate semialdehyde dehydrogenase|succinate-semialdehyde dehydrogenase
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Interactome
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Pathway
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Disease
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Publication Reference
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Novel ALDH5A1 variants and genotype: Phenotype correlation in SSADH deficiency.
Melissa L DiBacco, Ana Pop, Gajja S Salomons, Ellen Hanson, Jean-Baptiste Roullet, K Michael Gibson, Phillip L Pearl.
Neurology 2020 Nov; 95(19):e2675.
Application：WB-Tr, Human, HEK 293 cells.
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Novel ALDH5A1 variants and genotype: Phenotype correlation in SSADH deficiency.
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