NPHS2 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human NPHS2 full-length ORF ( AAH29141.1, 1 a.a. - 315 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MERRARSSSRESRGRGGRTPHKENKRAKAERSGGGRGRQEAGPEPSGSGRAGTPGEPRAPAATVVDVDEVRGSGEEGTEVVALLESERPEEGTKSSGLGACEWLLVLISLLFIIMTFPFSIWFCVKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDTYHKVDLRLQTLEIPFHEVALDSVTCIWGIKVERIEIKDVRLPAGLQHSLAVEAEAQRQAKVRMIAAEAEKAASESLRMAAEILSGTPAAVQLRYLHTLQSLSTEKPSTVVLPLPFDLLNCLSSPSNRTQGSLPFPSPSKPVEPLNPKKKDSPML
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
60.8
Interspecies Antigen Sequence
Mouse (80)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — NPHS2
Entrez GeneID
7827GeneBank Accession#
BC029141.1Protein Accession#
AAH29141.1Gene Name
NPHS2
Gene Alias
PDCN, SRN1
Gene Description
nephrosis 2, idiopathic, steroid-resistant (podocin)
Gene Ontology
HyperlinkGene Summary
This gene encodes the glomerular protein podocin which plays a role in the regulation of glomerular permeability, and acts as a linker between the plasma membrane and the cytoskeleton. Defects in this gene are the cause of autosomal recessive steroid-resistant nephrotic syndrome (SRN). SRN is characterized by onset between three months and five years, resistance to steroid therapy and rapid progression to end-stage renal disease. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq
Other Designations
OTTHUMP00000033186|podocin
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Interactome
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Disease
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Publication Reference
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Absolute quantification of podocin, a potential biomarker of glomerular injury in human urine, by Liquid Chromatography - Multiple Reaction Monitoring cubed Mass spectrometry.
Simon R, Lemoine J, Fonbonne C, Jaffuel A, Leonard JF, Gautier JC, Pasquier O, Salvador A.
Journal of Pharmaceutical and Biomedical Analysis 2014 Jun; 94:84.
Application:LCMS, Recombinant protein.
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Absolute quantification of podocin, a potential biomarker of glomerular injury in human urine, by Liquid Chromatography - Multiple Reaction Monitoring cubed Mass spectrometry.
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