VMD2 MaxPab mouse polyclonal antibody (B01)
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of BEST1 expression in transfected 293T cell line (H00007439-T01) by BEST1 MaxPab polyclonal antibody.
Lane 1: VMD2 transfected lysate(66.44 KDa).
Lane 2: Non-transfected lysate.
-
Specification
Product Description
Mouse polyclonal antibody raised against a full-length human VMD2 protein.
Immunogen
VMD2 (AAH41664.1, 1 a.a. ~ 604 a.a) full-length human protein.
Sequence
MFEKLTLYCDSYIQLIPISFVLGFYVTLVVTRWWNQYENLPWPDRLMSLVSGFVEGKDEQGRLLRRTLIRYANLGNVLILRSVSTAVYKRFPSAQHLVQAGFMTPAEHKQLEKLSLPHNMFWVPWVWFANLSMKAWLGGRIRDPILLQSLLNEMNTLRTQCGHLYAYDWISIPLVYTQVVTVAVYSFFLTCLVGRQFLNPAKAYPGHELDLVVPVFTFLQFFFYVGWLKVAEQLINPFGEDDDDFETNWIVDRNLQVSLLAVDEMHQDLPRMEPDMYWNKPEPQPPYTAASAQFRRVSFMGSTFNISLNKEEMEFQPNQEDEEDAHAGIIGRFLGLQSHDHHPPRANSRTKLLWPKRESLLHEGLPKNHKAAKQNVRGQEDNKAWKLKAVDAFKSAPLYQRPGYYSAPQTPLSPTPMFFPLEPSAPSKLHSVTGIDTKDKSLKTVSSGAKKSFELLSESDGALMEHPEVSQVRRKTVEFNLTDMPEIPENHLKEPLEQSPTNIHTTLKDHMDPYWALENRSVLHLNQGHCIALCPTPASLALSLPFLHNFLGFHHCQSTLDLRPALAWGIYLATFTGILGKCSGPFLTSPWYHPEDFLGPGEGR
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Note
For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
-
Applications
Western Blot (Transfected lysate)
Western Blot analysis of BEST1 expression in transfected 293T cell line (H00007439-T01) by BEST1 MaxPab polyclonal antibody.
Lane 1: VMD2 transfected lysate(66.44 KDa).
Lane 2: Non-transfected lysate.
-
Gene Info — BEST1
Entrez GeneID
7439GeneBank Accession#
BC041664.1Protein Accession#
AAH41664.1Gene Name
BEST1
Gene Alias
ARB, BEST, BMD, TU15B, VMD2
Gene Description
bestrophin 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms
Other Designations
Best disease|vitelliform macular dystrophy protein 2
-
Interactome
-
Disease
-
Publication Reference
-
Effects of alternative splicing on function of Bestrophin-1 calcium-activated chloride channels.
Kuo YH, Abdullaev IF, Hyzinski-Garcia MC, Mongin AA.
The Biochemical Journal 2014 Mar; 458(3):575.
Application：WB, Human, HEK 293 cells.
-
Effects of alternative splicing on function of Bestrophin-1 calcium-activated chloride channels.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com