UMOD purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
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Western Blot (Tissue lysate)
UMOD MaxPab rabbit polyclonal antibody. Western Blot analysis of UMOD expression in human kidney.
Western Blot (Transfected lysate)
Western Blot analysis of UMOD expression in transfected 293T cell line (H00007369-T02) by UMOD MaxPab polyclonal antibody.
Lane 1: UMOD transfected lysate(66.70 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human UMOD protein.
Immunogen
UMOD (AAH35975.1, 1 a.a. ~ 611 a.a) full-length human protein.
Sequence
MGQPSLTWMLMVVVASWFITTAATDTSEARWCSECHSNATCTEDEAVTTCTCQEGFTGDGLTCVDLDECAIPGAHNCSANSSCVNTPGSFSCVCPEGFRLSPGLGCTDVDECAEPGLSHCHALATCVNVVGSYLCVCPAGYRGDGWHCECSPGSCGPGLDCVPEGDALVCADPCQAHRTLDEYWRSTEYGEGYACDTDLRGWYRPHPSSDEGIVSRKACAHWSGHCCLWDASVQVKACAGGYYVYNLTAPPECHLAYCTDPSSVEGTCEECSIDEDCKSNNGRWHCQCKQDFNITDISLLEHRLECGANDMKVSLGKCQLKSLGFDKVFMYLSDSRCSGFNDRDNRDWVSVVTPARDGPCGTVLTRNETHATYSNTLYLADEIIIRDLNIKINFACSYPLDMKVSLKTALQPMVSALNIRVGGTGMFTVRMALFQTPSYTQPYQGSSVTLSTEAFLYVGTMLDGGDLSRFALLMTNCYATPSSNATDPLKYFIIQDRCPHTRDSTIQVVENGESSQGRFSVQMFRFAGNYDLVYLHCEVYLCDTMNEKCKPTCSGTRFRSGSVIDQSRVLNLGPITRKGVQATVSRAFSSLGLLKVWLPLLLSATLTLTFQ
Host
Rabbit
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
UMOD MaxPab rabbit polyclonal antibody. Western Blot analysis of UMOD expression in human kidney.Western Blot (Transfected lysate)
Western Blot analysis of UMOD expression in transfected 293T cell line (H00007369-T02) by UMOD MaxPab polyclonal antibody.
Lane 1: UMOD transfected lysate(66.70 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — UMOD
Entrez GeneID
7369GeneBank Accession#
BC035975Protein Accession#
AAH35975.1Gene Name
UMOD
Gene Alias
ADMCKD2, FJHN, HNFJ, MCKD2, THGP, THP
Gene Description
uromodulin
Gene Ontology
HyperlinkGene Summary
This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform. [provided by RefSeq
Other Designations
OTTHUMP00000162212|Tamm-Horsfall glycoprotein|uromodulin (uromucoid, Tamm-Horsfall glycoprotein)|uromucoid
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Interactome
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Disease
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