UCP2 purified MaxPab mouse polyclonal antibody (B03P)
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More Files
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human UCP2 protein.
Immunogen
UCP2 (AAH11737.1, 1 a.a. ~ 309 a.a) full-length human protein.
Sequence
MVGFKATDVPPTATVKFLGAGTAACIADLITFPLGTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRALMAACTSREAPF
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of UCP2 expression in transfected 293T cell line (H00007351-T03) by UCP2 MaxPab polyclonal antibody.
Lane 1: UCP2 transfected lysate(34.10 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — UCP2
Entrez GeneID
7351GeneBank Accession#
BC011737.2Protein Accession#
AAH11737.1Gene Name
UCP2
Gene Alias
BMIQ4, SLC25A8, UCPH
Gene Description
uncoupling protein 2 (mitochondrial, proton carrier)
Gene Ontology
HyperlinkGene Summary
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq
Other Designations
uncoupling protein 2|uncoupling protein-2
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Interactome
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Disease
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