Immunoprecipitation of TNNT2 transfected lysate using anti-TNNT2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with TNNT2 MaxPab mouse polyclonal antibody (B01) (H00007139-B01).
The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq
OTTHUMP00000033864,OTTHUMP00000033867,cardiomyopathy, dilated 1D (autosomal dominant),cardiomyopathy, hypertrophic 2,troponin T type 2, cardiac,troponin T, cardiac muscle,troponin T2, cardiac