TLR4 (Human) Recombinant Protein (Q01)
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More Files
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Specifications
Product Description
Human TLR4 partial ORF ( NP_612564, 214 a.a. - 291 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
PMNFIQPGAFKEIRLHKLTLRNNFDSLNVMKTCIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFRLA
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
34.32
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — TLR4
Entrez GeneID
7099GeneBank Accession#
NM_138554Protein Accession#
NP_612564Gene Name
TLR4
Gene Alias
ARMD10, CD284, TOLL, hToll
Gene Description
toll-like receptor 4
Omim ID
603030Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq
Other Designations
OTTHUMP00000022807|homolog of Drosophila toll
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Interactomes
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Pathways
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Diseases
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Publication Reference
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CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation.
Hayakawa K, Pham LD, Seo JH, Miyamoto N, Maki T, Terasaki Y, Sakadžić S, Boas D, van Leyen K, Waeber C, Kim KW, Arai K, Lo EH.
Journal of Cerebral Blood Flow and Metabolism 2016 Apr; 36(4):781.
Application:Pull-Down, Rat, Oligodendrocyte precursor cells.
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Analysis of Mechanistic Pathway Models in Drug Discovery: p38 Pathway.
Hendriks BS, Hua F, Chabot JR.
Biotechnology Progress 2007 Oct; 24(1):96.
Application:Quant, WB, Human, U937 cells.
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CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation.
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