LEFTY2 (Human) Recombinant Protein (P01)
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More Files
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Specifications
Product Description
Human LEFTY2 full-length ORF ( NP_003231.2, 1 a.a. - 366 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MWPLWLCWALWVLPLAGPGAALTEEQLLGSLLRQLQLSEVPVLDRADMEKLVIPAHVRAQYVVLLRRSHGDRSRGKRFSQSFREVAGRFLASEASTHLLVFGMEQRLPPNSELVQAVLRLFQEPVPKAALHRHGRLSPRSAQARVTVEWLRVRDDGSNRTSLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQPLLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQLELHTLDLRDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQGMKWAKNWVLEPPGFLAYECVGTCQQPPEALAFNWPFLGPRQCIASETASLPMIVSIKEGGRTRPQVVSLPNMRVQKCSCASDGALVPRRLQP
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
67.3
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — LEFTY2
Entrez GeneID
7044GeneBank Accession#
NM_003240.2Protein Accession#
NP_003231.2Gene Name
LEFTY2
Gene Alias
EBAF, LEFTA, LEFTYA, MGC46222, TGFB4
Gene Description
left-right determination factor 2
Omim ID
601877Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. The protein may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq
Other Designations
OTTHUMP00000035570|endometrial bleeding associated factor|endometrial bleeding associated factor (left-right determination, factor A; transforming growth factor beta superfamily)|transforming growth factor, beta-4 (endometrial bleeding-associated factor;
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Interactomes
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Pathways
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Diseases
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