TCF7L2 (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human TCF7L2 full-length ORF ( AAH32656, 1 a.a. - 455 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGSLSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPPNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITGEKKSAFATYKVKAAASAHPLQMEAY
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
75.79
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — TCF7L2
Entrez GeneID
6934GeneBank Accession#
BC032656Protein Accession#
AAH32656Gene Name
TCF7L2
Gene Alias
TCF-4, TCF4
Gene Description
transcription factor 7-like 2 (T-cell specific, HMG-box)
Gene Ontology
HyperlinkGene Summary
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes
Other Designations
OTTHUMP00000020496|transcription factor 7-like 2
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Interactome
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Pathway
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Disease
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Publication Reference
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Inhibition of Wnt signaling in colon cancer cells via an oral drug that facilitates TNIK degradation.
Kun Zhou, Jae Eun Cheong, Subrahmanian Tarakkad Krishnaji, Aram Ghalali, Haojie Fu, Lufei Sui, Catherine Alix-Panabieres, Laure Cayrefourcq, Diane Bielenberg, Lijun Sun, Bruce R Zetter.
2022 Oct; MCT-21-0801.
Application:KA, Recombinant proteins.
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Regulation of Wnt Signaling by the Nuclear Pore Complex.
Shitashige M, Satow R, Honda K, Ono M, Hirohashi S, Yamada T.
Gastroenterology 2008 Mar; 134(7):1961.
Application:Func, WB, Recombinant protein.
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Inhibition of Wnt signaling in colon cancer cells via an oral drug that facilitates TNIK degradation.
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