TCF7L2 monoclonal antibody (M02), clone 1B1
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More Files
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Western Blot (Cell lysate)
TCF7L2 monoclonal antibody (M02), clone 1B1 Western Blot analysis of TCF7L2 expression in Hela S3 NE ( Cat # L013V3 ).
Western Blot (Transfected lysate)
Western Blot analysis of TCF7L2 expression in transfected 293T cell line by TCF7L2 monoclonal antibody (M02), clone 1B1.
Lane 1: TCF7L2 transfected lysate(50.6 KDa).
Lane 2: Non-transfected lysate.
RNAi Knockdown (Antibody validated)
Western blot analysis of TCF7L2 over-expressed 293 cell line, cotransfected with TCF7L2 Validated Chimera RNAi ( Cat # H00006934-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with TCF7L2 monoclonal antibody (M02), clone 1B1 (Cat # H00006934-M02 ). GAPDH ( 36.1 kDa ) used as specificity and loading control.
Western Blot detection against Immunogen (75.79 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a full length recombinant TCF7L2.
Immunogen
TCF7L2 (AAH32656, 1 a.a. ~ 455 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MPQLNGGGGDDLGANDELISFKDEGEQEEKSSENSSAERDLADVKSSLVNESETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGSLSPTARTYLQMKWPLLDVQAGSLQSRQALKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPPNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITGEKKSAFATYKVKAAASAHPLQMEAY
Host
Mouse
Reactivity
Human
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (75.79 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
TCF7L2 monoclonal antibody (M02), clone 1B1 Western Blot analysis of TCF7L2 expression in Hela S3 NE ( Cat # L013V3 ).Western Blot (Transfected lysate)
Western Blot analysis of TCF7L2 expression in transfected 293T cell line by TCF7L2 monoclonal antibody (M02), clone 1B1.
Lane 1: TCF7L2 transfected lysate(50.6 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
ELISA
RNAi Knockdown (Antibody validated)
Western blot analysis of TCF7L2 over-expressed 293 cell line, cotransfected with TCF7L2 Validated Chimera RNAi ( Cat # H00006934-R01V ) (Lane 2) or non-transfected control (Lane 1). Blot probed with TCF7L2 monoclonal antibody (M02), clone 1B1 (Cat # H00006934-M02 ). GAPDH ( 36.1 kDa ) used as specificity and loading control. -
Gene Info — TCF7L2
Entrez GeneID
6934GeneBank Accession#
BC032656Protein Accession#
AAH32656Gene Name
TCF7L2
Gene Alias
TCF-4, TCF4
Gene Description
transcription factor 7-like 2 (T-cell specific, HMG-box)
Gene Ontology
HyperlinkGene Summary
This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes
Other Designations
OTTHUMP00000020496|transcription factor 7-like 2
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Interactome
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Pathway
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Disease
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Publication Reference
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TCF7L2 regulates late events in insulin secretion from pancreatic islet {beta}-cells.
da Silva Xavier G, Loder MK, McDonald A, Tarasov AI, Carzaniga R, Kronenberger K, Barg S, Rutter GA.
Diabetes 2009 Apr; 58(4):894.
Application：WB-Ti, WB-Tr, Mouse, Rat, Islets, MIN6, INS-1 cells.
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TCF7L2 regulates late events in insulin secretion from pancreatic islet {beta}-cells.
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