TBCE purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
TBCE MaxPab polyclonal antibody. Western Blot analysis of TBCE expression in human spleen.
Western Blot (Cell lysate)
TBCE MaxPab polyclonal antibody. Western Blot analysis of TBCE expression in HepG2.
Western Blot (Transfected lysate)
Western Blot analysis of TBCE expression in transfected 293T cell line (H00006905-T02) by TBCE MaxPab polyclonal antibody.
Lane 1: TBCE transfected lysate(57.97 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human TBCE protein.
Immunogen
TBCE (AAH08654, 1 a.a. ~ 527 a.a) full-length human protein.
Sequence
MSDTLTADVIGRRVEVNGEHATVRFAGVVPPVAGPWLGVEWDNPERGKHDGSHEGTVYFKCRHPTGGSFIRPNKVNFGTDFLTAIKNRYVLEDGPEEDRKEQIVTIGNKPVETIGFDSIMKQQSQLSKLQEVSLRNCAVSCAGEKGGVAEACPNIRKVDLSKNLLSSWDEVIHIADQLRHLEVLNVSENKLKFPSGSVLTGTLSVLKVLVLNQTGITWAEVLRCVAGCPGLEELYLESNNIFISERPTDVLQTVKLLDLSSNQLIDENQLYLIAHLPRLEQLILSDTGISSLHFPDAGIGCKTSMFPSLKYLVVNDNQISQWSFFNELEKLPSLRALSCLRNPLTKEDKEAETARLLIIASIGQLKTLNKCEILPEERRRAELDYRKAFGNEWKQAGGHKDPEKNRLSEEFLTAHPRYQFLCLKYGAPEDWELKTQQPLMLKNQLLTLKIKYPHQLDQKVLEKQLPGSMTIQKVKGLLSRLLKVPVSDLLLSYESPKKPGREIELENDLKSLQFYSVENGDCLLVRW
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (74); Rat (75)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
TBCE MaxPab polyclonal antibody. Western Blot analysis of TBCE expression in human spleen.Western Blot (Cell lysate)
TBCE MaxPab polyclonal antibody. Western Blot analysis of TBCE expression in HepG2.Western Blot (Transfected lysate)
Western Blot analysis of TBCE expression in transfected 293T cell line (H00006905-T02) by TBCE MaxPab polyclonal antibody.
Lane 1: TBCE transfected lysate(57.97 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — TBCE
Entrez GeneID
6905GeneBank Accession#
BC008654Protein Accession#
AAH08654Gene Name
TBCE
Gene Alias
HRD, KCS, KCS1, pac2
Gene Description
tubulin folding cofactor E
Gene Ontology
HyperlinkGene Summary
Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000037906|beta-tubulin cofactor E|tubulin-specific chaperone e
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Interactome
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Disease
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Publication Reference
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Golgi fragmentation in pmn mice is due to a defective ARF1/TBCE cross-talk that coordinates COPI vesicle formation and tubulin polymerization.
Bellouze S, Schafer MK, Buttigieg D, Baillat G, Rabouille C, Haase G.
Human Molecular Genetics 2014 Nov; 23(22):5961.
Application：IF, Mouse, NSC34 cells, Spinal cord.
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Golgi fragmentation in pmn mice is due to a defective ARF1/TBCE cross-talk that coordinates COPI vesicle formation and tubulin polymerization.
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