RASA1 monoclonal antibody (M01A), clone 2C12
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More Files
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Western Blot (Cell lysate)
RASA1 monoclonal antibody (M01A), clone 2C12 Western Blot analysis of RASA1 expression in IMR-32 ( Cat # L008V1 ).
Western Blot detection against Immunogen (36.74 KDa) .
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant RASA1.
Immunogen
RASA1 (NP_002881, 948 a.a. ~ 1047 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
AKEPYMEGVNPFIKSNKHRMIMFLDELGNVPELPDTTEHSRTDLSRDLAALHEICVAHSDELRTLSNERGAQQHVLKKLLAITELLQQKQNQYTKTNDVR
Host
Mouse
Reactivity
Human
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In ascites fluid
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
RASA1 monoclonal antibody (M01A), clone 2C12 Western Blot analysis of RASA1 expression in IMR-32 ( Cat # L008V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — RASA1
Entrez GeneID
5921GeneBank Accession#
NM_002890Protein Accession#
NP_002881Gene Name
RASA1
Gene Alias
CM-AVM, CMAVM, DKFZp434N071, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP
Gene Description
RAS p21 protein activator (GTPase activating protein) 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq
Other Designations
GTPase activating protein|RAS p21 protein activator 1|triphosphatase-activating protein
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Interactome
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Pathway
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Disease
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