PSAP MaxPab rabbit polyclonal antibody (D01)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of PSAP expression in transfected 293T cell line (H00005660-T01) by PSAP MaxPab polyclonal antibody.
Lane 1: PSAP transfected lysate(58.1 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of PSAP transfected lysate using anti-PSAP MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with PSAP purified MaxPab mouse polyclonal antibody (B01P) (H00005660-B01P).
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human PSAP protein.
Immunogen
PSAP (NP_002769.1, 1 a.a. ~ 524 a.a) full-length human protein.
Sequence
MYALFLLASLLGAALAGPVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN
Host
Rabbit
Reactivity
Human
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of PSAP expression in transfected 293T cell line (H00005660-T01) by PSAP MaxPab polyclonal antibody.
Lane 1: PSAP transfected lysate(58.1 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of PSAP transfected lysate using anti-PSAP MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with PSAP purified MaxPab mouse polyclonal antibody (B01P) (H00005660-B01P). -
Gene Info — PSAP
Entrez GeneID
5660GeneBank Accession#
NM_002778.2Protein Accession#
NP_002769.1Gene Name
PSAP
Gene Alias
FLJ00245, GLBA, MGC110993, SAP1
Gene Description
prosaposin
Gene Ontology
HyperlinkGene Summary
This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
OTTHUMP00000019776|sphingolipid activator protein-1
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Interactome
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Pathway
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Disease
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Publication Reference
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Co-localization of cystatin C and prosaposin in cultured neurons and in anterior horn neurons with amyotrophic lateral sclerosis.
Wada Y, Nagai A, Sheikh AM, Onoda K, Terashima M, Shiota Y, Araki A, Yamaguchi S.
Journal of the Neurological Sciences 2018 Jan; 384:67.
Application：IF, WB-Re, Human, A1 neuronal hybrid cell line, Recombinant protein, Spinal cord from patients with amyotrophic lateral sclerosis.
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Co-localization of cystatin C and prosaposin in cultured neurons and in anterior horn neurons with amyotrophic lateral sclerosis.
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