PSAP polyclonal antibody (A01)
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More Files
- More Functions
Western Blot detection against Immunogen (81.88 KDa) .
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length recombinant PSAP.
Immunogen
PSAP (AAH01503, 18 a.a. ~ 524 a.a) full-length recombinant protein with GST tag.
Sequence
PVLGLKECTRGSAVWCQNVKTASDCGAVKHCLQTVWNKPTVKSLPCDICKDVVTAAGDMLKDNATEEEILVYLEKTCDWLPKPNMSASCKEIVDSYLPVILDIIKGEMSRPGEVCSALNLCESLQKHLAELNHQKQLESNKIPELDMTEVVAPFMANIPLLLYPQDGPRSKPQPKDNGDVCQDCIQMVTDIQTAVRTNSTFVQALVEHVKEECDRLGPGMADICKNYISQYSEIAIQMMMHMQPKEICALVGFCDEVKEMPMQTLVPAKVASKNVIPALELVEPIKKHEVPAKSDVYCEVCEFLVKEVTKLIDNNKTEKEILDAFDKMCSKLPKSLSEECQEVVDTYGSSILSILLEEVSPELVCSMLHLCSGTRLPALTVHVTQPKDGGFCEVCKKLVGYLDRNLEKNSTKQEILAALEKGCSFLPDPYQKQCDQFVAEYEPVLIEILVEVMDPSFVCLKIGACPSAHKPLLGTEKCIWGPSYWCQNTETAAQCNAVEHCKRHVWN
Host
Mouse
Reactivity
Human
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (81.88 KDa) .
Storage Buffer
50 % glycerol
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
ELISA
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Gene Info — PSAP
Entrez GeneID
5660GeneBank Accession#
BC001503Protein Accession#
AAH01503Gene Name
PSAP
Gene Alias
FLJ00245, GLBA, MGC110993, SAP1
Gene Description
prosaposin
Gene Ontology
HyperlinkGene Summary
This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
OTTHUMP00000019776|sphingolipid activator protein-1
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Interactome
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Pathway
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Disease
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Publication Reference
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Co-localization of cystatin C and prosaposin in cultured neurons and in anterior horn neurons with amyotrophic lateral sclerosis.
Wada Y, Nagai A, Sheikh AM, Onoda K, Terashima M, Shiota Y, Araki A, Yamaguchi S.
Journal of the Neurological Sciences 2018 Jan; 384:67.
Application：IF, WB-Re, Human, A1 neuronal hybrid cell line, Recombinant protein, Spinal cord from patients with amyotrophic lateral sclerosis.
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Co-localization of cystatin C and prosaposin in cultured neurons and in anterior horn neurons with amyotrophic lateral sclerosis.
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