PRF1 293T Cell Transient Overexpression Lysate(Denatured)
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Transfected Cell Line
293T
Plasmid
pCMV-PRF1 full-length
Host
Human
Theoretical MW (kDa)
61.4
Interspecies Antigen Sequence
Mouse (69); Rat (69)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-PRF1 antibody (H00005551-B01P) by Western Blots.
SDS-PAGE Gel
PRF1 transfected lysate.
Western Blot
Lane 1: PRF1 transfected lysate ( 61.40 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
-
Applications
Western Blot
-
Gene Info — PRF1
Entrez GeneID
5551GeneBank Accession#
NM_005041Protein Accession#
NP_005032.2Gene Name
PRF1
Gene Alias
FLH2, HPLH2, MGC65093, P1, PFN1, PFP
Gene Description
perforin 1 (pore forming protein)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq
Other Designations
OTTHUMP00000019759|cytolysin|lymphocyte pore forming protein|perforin 1
-
Interactome
-
Pathway
-
Disease
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com