PHF1 monoclonal antibody (M01), clone 2D3
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a partial recombinant PHF1.
Immunogen
PHF1 (NP_077084, 2 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
AQPPRLSRSGASSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVP
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (97); Rat (97)
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.63 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
PHF1 monoclonal antibody (M01), clone 2D3 Western Blot analysis of PHF1 expression in A-431 ( Cat # L015V1 ).Western Blot (Recombinant protein)
ELISA
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Gene Info — PHF1
Entrez GeneID
5252GeneBank Accession#
NM_024165Protein Accession#
NP_077084Gene Name
PHF1
Gene Alias
MTF2L2, PCL1, PHF2
Gene Description
PHD finger protein 1
Omim ID
602881Gene Ontology
HyperlinkGene Summary
This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000029139|OTTHUMP00000029140
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Interactome
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Disease
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Publication Reference
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Val97Leu mutant presenilin-1 induces tau hyperphosphorylation and spatial memory deficit in mice and the underlying mechanisms.
Wang Y, Cheng Z, Qin W, Jia J.
Journal of Neurochemistry 2012 Apr; 121(1):135.
Application:ICC, IHC, WB-Ti, WB-Tr, Mouse, Mouse hippocampus, N2a cells.
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A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell.
Hong Z, Jiang J, Lan L, Nakajima S, Kanno SI, Koseki H, Yasui A.
Nucleic Acids Research 2008 Apr; 36(9):2939.
Application:IF, WB, Human, Flp-In-293, HeLa cells.
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Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1.
Lazarov O, Morfini GA, Pigino G, Gadadhar A, Chen X, Robinson J, Ho H, Brady ST, Sisodia SS.
Journal of Neuroscience 2007 Jun; 27(26):7011.
Application:WB, Mouse, Mouse lumbar spinal cord.
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Val97Leu mutant presenilin-1 induces tau hyperphosphorylation and spatial memory deficit in mice and the underlying mechanisms.
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