P4HB purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
P4HB MaxPab polyclonal antibody. Western Blot analysis of P4HB expression in human liver.
Western Blot (Cell lysate)
P4HB MaxPab polyclonal antibody. Western Blot analysis of P4HB expression in HeLa.
Western Blot (Transfected lysate)
Western Blot analysis of P4HB expression in transfected 293T cell line (H00005034-T01) by P4HB MaxPab polyclonal antibody.
Lane 1: P4HB transfected lysate(55.88 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to P4HB on HeLa cell. [antibody concentration 10 ug/ml]
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human P4HB protein.
Immunogen
P4HB (NP_000909.2, 1 a.a. ~ 508 a.a) full-length human protein.
Sequence
MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAIDDIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITLEEEMTKYKPESEELTAERITEFCHRFLEGKIKPHLMSQELPEDWDKQPVKVLVGKNFEDVAFDEKKNVFVEFYAPWCGHCKQLAPIWDKLGETYKDHENIVIAKMDSTANEVEAVKVHSFPTLKFFPASADRTVIDYNGERTLDGFKKFLESGGQDGAGDDDDLEDLEEAEEPDMEEDDDQKAVKDEL
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (95)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
P4HB MaxPab polyclonal antibody. Western Blot analysis of P4HB expression in human liver.Western Blot (Cell lysate)
P4HB MaxPab polyclonal antibody. Western Blot analysis of P4HB expression in HeLa.Western Blot (Transfected lysate)
Western Blot analysis of P4HB expression in transfected 293T cell line (H00005034-T01) by P4HB MaxPab polyclonal antibody.
Lane 1: P4HB transfected lysate(55.88 KDa).
Lane 2: Non-transfected lysate.
Immunofluorescence
Immunofluorescence of purified MaxPab antibody to P4HB on HeLa cell. [antibody concentration 10 ug/ml] -
Gene Info — P4HB
Entrez GeneID
5034GeneBank Accession#
NM_000918.2Protein Accession#
NP_000909.2Gene Name
P4HB
Gene Alias
DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB
Gene Description
prolyl 4-hydroxylase, beta polypeptide
Omim ID
176790Gene Ontology
HyperlinkGene Summary
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq
Other Designations
collagen prolyl 4-hydroxylase beta|glutathione-insulin transhydrogenase|procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide|prolyl 4-hydroxylase, beta subunit|protein disulfide isomerase family A, member 1|protein d
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Interactome
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Disease
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