NTRK2 monoclonal antibody (M02), clone 3D12
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant NTRK2.
Immunogen
NTRK2 (AAH31835, 1 a.a. ~ 477 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGFVLFHKIPLDG
Host
Mouse
Reactivity
Human
Isotype
IgG2a kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (78.21 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
-
Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged NTRK2 is approximately 0.3ng/ml as a capture antibody.ELISA
-
Gene Info — NTRK2
Entrez GeneID
4915GeneBank Accession#
BC031835Protein Accession#
AAH31835Gene Name
NTRK2
Gene Alias
GP145-TrkB, TRKB
Gene Description
neurotrophic tyrosine kinase, receptor, type 2
Omim ID
600456Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
BDNF/NT-3 growth factors receptor|OTTHUMP00000021573|OTTHUMP00000021574|OTTHUMP00000021575|OTTHUMP00000021576|OTTHUMP00000021577|tyrosine kinase receptor B
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
The brain-derived neurotrophic factor prompts platelet aggregation and secretion.
Imane Boukhatem, Samuel Fleury, Melanie Welman, Jessica Le Blanc, Chantal Thys, Kathleen Freson, Myron G Best, Thomas Würdinger, Bruce G Allen, Marie Lordkipanidzé.
Blood Advances 2021 Sep; 5(18):3568.
Application:WB-Ce, WB-Ti, Human, Human cortex, Human platelets.
-
Tissue-Specificity of Antibodies Raised Against TrkB and p75 NTR Receptors; Implications for Platelets as Models of Neurodegenerative Diseases.
Samuel Fleury, Imane Boukhatem, Jessica Le Blanc, Mélanie Welman, Marie Lordkipanidzé.
Frontiers in Immunology 2021 Feb; 12:606861.
Application:WB-Ti, Human, Human cerebral cortex, Human platelet.
-
Pharmacological characterization of six trkB antibodies reveals a novel class of functional agents for the study of the BDNF receptor.
Cazorla M, Arrang JM, Premont J.
British Journal of Pharmacology 2011 Feb; 162(4):947.
Application:WB, Human, Mouse, CHO, PC12 cells, Cortical neuron.
-
The brain-derived neurotrophic factor prompts platelet aggregation and secretion.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com