NDUFS2 purified MaxPab mouse polyclonal antibody (B01P)
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More Files
- More Functions
Western Blot (Tissue lysate)
NDUFS2 MaxPab polyclonal antibody. Western Blot analysis of NDUFS2 expression in human kidney.
Western Blot (Transfected lysate)
Western Blot analysis of NDUFS2 expression in transfected 293T cell line (H00004720-T01) by NDUFS2 MaxPab polyclonal antibody.
Lane 1: NDUFS2 transfected lysate(50.93 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Mouse polyclonal antibody raised against a full-length human NDUFS2 protein.
Immunogen
NDUFS2 (NP_004541.1, 1 a.a. ~ 463 a.a) full-length human protein.
Sequence
MAALRALCGFRGVAAQVLRPGAGVRLPIQPSRGVRQWQPDVEWAQQFGGAVMYPSKETAHWKPPPWNDVDPPKDTIVKNITLNFGPQHPAAHGVLRLVMELSGEMVRKCDPHIGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSLAVEKLLNIRPPPRAQWIRVLFGEITRLLNHIMAVTTHALDLGAMTPFFWLFEEREKMFEFYERVSGARMHAAYIRPGGVHQDLPLGLMDDIYQFSKNFSLRLDELEELLTNNRIWRNRTIDIGVVTAEEALNYGFSGVMLRGSGIQWDLRKTQPYDVYDQVEFDVPVGSRGDCYDRYLCRVEEMRQSLRIIAQCLNKMPPGEIKVDDAKVSPPKRAEMKTSMESLIHHFKLYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPYRCKIKAPGFAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEVDR
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (92); Rat (92)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
NDUFS2 MaxPab polyclonal antibody. Western Blot analysis of NDUFS2 expression in human kidney.Western Blot (Transfected lysate)
Western Blot analysis of NDUFS2 expression in transfected 293T cell line (H00004720-T01) by NDUFS2 MaxPab polyclonal antibody.
Lane 1: NDUFS2 transfected lysate(50.93 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — NDUFS2
Entrez GeneID
4720GeneBank Accession#
NM_004550.3Protein Accession#
NP_004541.1Gene Name
NDUFS2
Gene Alias
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Gene Description
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
Gene Ontology
HyperlinkGene Summary
Mitochondrial complex I (NADH-ubiquinone reductase; EC 1.6.5.3) is the first multimeric complex of the respiratory chain that catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mammalian mitochondrial complex I is an assembly of at least 43 different subunits. Seven of the subunits are encoded by the mitochondrial genome; the remainder are the products of nuclear genes. The iron-sulfur protein (IP) fraction of complex I is made up of 7 subunits, including NDUFS2. See NDUFS1 (MIM 157655).[supplied by OMIM
Other Designations
NADH dehydrogenase (ubiquinone) Fe-S protein 2|NADH-ubiquinone oxidoreductase Fe-S protein 2|NADH-ubiquinone oxidoreductase NDUFS2 subunit|OTTHUMP00000032241
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Interactome
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Pathway
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Disease
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Publication Reference
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Compound heterozygosity for severe and hypomorphic NDUFS2 mutations cause non-syndromic LHON-like optic neuropathy.
Gerber S, Ding MG, Gérard X, Zwicker K, Zanlonghi X, Rio M, Serre V, Hanein S, Munnich A, Rotig A, Bianchi L, Amati-Bonneau P, Elpeleg O, Kaplan J, Brandt U, Rozet JM.
Journal of Medical Genetics 2016 Dec; [Epub].
Application：WB, Human, Patient-derived cultured skin fibroblast.
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Compound heterozygosity for severe and hypomorphic NDUFS2 mutations cause non-syndromic LHON-like optic neuropathy.
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