MMP12 purified MaxPab rabbit polyclonal antibody (D01P)
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More Files
- More Functions
Western Blot (Cell lysate)
MMP12 MaxPab rabbit polyclonal antibody. Western Blot analysis of MMP12 expression in HeLa.
Western Blot (Cell lysate)
MMP12 MaxPab rabbit polyclonal antibody. Western Blot analysis of MMP12 expression in PC-12.
Western Blot (Transfected lysate)
Western Blot analysis of MMP12 expression in transfected 293T cell line (H00004321-T01) by MMP12 MaxPab polyclonal antibody.
Lane 1: MMP12 transfected lysate(54.00 KDa).
Lane 2: Non-transfected lysate.
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human MMP12 protein.
Immunogen
MMP12 (NP_002417.2, 1 a.a. ~ 470 a.a) full-length human protein.
Sequence
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
Host
Rabbit
Reactivity
Human, Rat
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
MMP12 MaxPab rabbit polyclonal antibody. Western Blot analysis of MMP12 expression in HeLa.Western Blot (Cell lysate)
MMP12 MaxPab rabbit polyclonal antibody. Western Blot analysis of MMP12 expression in PC-12.Western Blot (Transfected lysate)
Western Blot analysis of MMP12 expression in transfected 293T cell line (H00004321-T01) by MMP12 MaxPab polyclonal antibody.
Lane 1: MMP12 transfected lysate(54.00 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — MMP12
Entrez GeneID
4321GeneBank Accession#
NM_002426Protein Accession#
NP_002417.2Gene Name
MMP12
Gene Alias
HME, MGC138506, MME
Gene Description
matrix metallopeptidase 12 (macrophage elastase)
Omim ID
601046Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq
Other Designations
macrophage elastase|macrophage metalloelastase|matrix metalloproteinase 12|matrix metalloproteinase 12 (macrophage elastase)
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Interactome
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Disease
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