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MDM2 293T Cell Transient Overexpression Lysate(Denatured)

  • Catalog # : H00004193-T01
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  • Specification
  • Transfected Cell Line:
  • 293T
  • Plasmid:
  • pCMV-MDM2 full-length
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 55.2
  • Quality Control Testing:
  • Transient overexpression cell lysate was tested with Anti-MDM2 antibody (H00004193-D01) by Western Blots.
    SDS-PAGE Gel
    QC Testing of H00004193-T01
    MDM2 transfected lysate.
    Western Blot
    QC Testing of H00004193-T01
    Lane 1: MDM2 transfected lysate ( 55.20 KDa)
    Lane 2: Non-transfected lysate.
  • Storage Buffer:
  • 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
  • Storage Instruction:
  • Store at -80°C. Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 4193
  • Gene Name:
  • MDM2
  • Gene Alias:
  • HDMX,MGC71221,hdm2
  • Gene Description:
  • Mdm2 p53 binding protein homolog (mouse)
  • Gene Summary:
  • This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq
  • Other Designations:
  • Mdm2, transformed 3T3 cell double minute 2, p53 binding protein,double minute 2, human homolog of; p53-binding protein,mouse double minute 2 homolog,p53-binding protein MDM2,ubiquitin-protein ligase E3 Mdm2
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