MCM7 MaxPab rabbit polyclonal antibody (D01)
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More Files
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Western Blot (Tissue lysate)
MCM7 MaxPab rabbit polyclonal antibody. Western Blot analysis of MCM7 expression in mouse lung.
Western Blot (Transfected lysate)
Western Blot analysis of MCM7 expression in transfected 293T cell line (H00004176-T01) by MCM7 MaxPab polyclonal antibody.
Lane 1: MCM7 transfected lysate(81.30 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of MCM7 transfected lysate using anti-MCM7 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with MCM7 purified MaxPab mouse polyclonal antibody (B01P) (H00004176-B01P).
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human MCM7 protein.
Immunogen
MCM7 (NP_005907.3, 1 a.a. ~ 719 a.a) full-length human protein.
Sequence
MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVRSPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV
Host
Rabbit
Reactivity
Human, Mouse
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Tissue lysate)
MCM7 MaxPab rabbit polyclonal antibody. Western Blot analysis of MCM7 expression in mouse lung.Western Blot (Transfected lysate)
Western Blot analysis of MCM7 expression in transfected 293T cell line (H00004176-T01) by MCM7 MaxPab polyclonal antibody.
Lane 1: MCM7 transfected lysate(81.30 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of MCM7 transfected lysate using anti-MCM7 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with MCM7 purified MaxPab mouse polyclonal antibody (B01P) (H00004176-B01P). -
Gene Info — MCM7
Entrez GeneID
4176GeneBank Accession#
NM_005916Protein Accession#
NP_005907.3Gene Name
MCM7
Gene Alias
CDABP0042, CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS-146
Gene Description
minichromosome maintenance complex component 7
Omim ID
600592Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
DNA replication licensing factor MCM7|MCM7 minichromosome maintenance deficient 7|homolog of S. cerevisiae Cdc47|minichromosome maintenance deficient 7
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Interactome
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Pathway
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Disease
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