LDLR 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-LDLR full-length
Host
Human
Theoretical MW (kDa)
94.6
Interspecies Antigen Sequence
Mouse (79)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-LDLR antibody (H00003949-B01) by Western Blots.
SDS-PAGE Gel
LDLR transfected lysate
Western Blot
Lane 1: LDLR transfected lysate ( 94.6 KDa).
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — LDLR
Entrez GeneID
3949GeneBank Accession#
BC014514Protein Accession#
AAH14514Gene Name
LDLR
Gene Alias
FH, FHC
Gene Description
low density lipoprotein receptor
Gene Ontology
HyperlinkGene Summary
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. [provided by RefSeq
Other Designations
LDL receptor|low-density lipoprotein receptor class A domain-containing protein 3
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