KRAS monoclonal antibody (M05), clone 1E4-1B10
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More Files
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Specification
Product Description
Mouse monoclonal antibody raised against a full-length recombinant KRAS.
Immunogen
KRAS (AAH13572, 1 a.a. ~ 188 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGHEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKKKKSKTKCVIM
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (97); Rat (97)
Isotype
IgG3 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (46.42 KDa) .
Storage Buffer
In 1x PBS, pH 7.4
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Recombinant protein)
Sandwich ELISA (Recombinant protein)
Detection limit for recombinant GST tagged KRAS is 3 ng/ml as a capture antibody.ELISA
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Gene Info — KRAS
Entrez GeneID
3845GeneBank Accession#
BC013572Protein Accession#
AAH13572Gene Name
KRAS
Gene Alias
C-K-RAS, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS3, RASK2
Gene Description
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Gene Ontology
HyperlinkGene Summary
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq
Other Designations
K-ras p21 protein|Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog|PR310 c-K-ras oncogene|c-K-ras2 protein|c-Kirsten-ras protein|cellular c-Ki-ras2 proto-oncogene|oncogene KRAS2|transforming protein p21|v-Ki-ras2 Kirsten rat sarcoma 2 viral oncoge
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Interactome
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Pathway
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Disease
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Publication Reference
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Treatment effects of the EGFR pathway drugs on head and neck cancer stem cells.
Glaucia Maria de Mendonça Fernandes, Vilson Serafim Junior, Ana Lívia Silva Galbiatti-Dias, Leticia Antunes Muniz Ferreira, Márcia Maria Urbanin Castanhole-Nunes, Rosa Sayoko Kawasaki-Oyama, José Victor Maniglia, Erika Cristina Pavarino, Eny Maria Goloni-Bertollo.
American Journal of Cancer Research 2022 Sep; 12(9):4196.
Application:WB, Mouse, Mouse head and neck cancer stem cell.
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Treatment effects of the EGFR pathway drugs on head and neck cancer stem cells.
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