IL12RB1 293T Cell Transient Overexpression Lysate(Denatured)
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Specification
Transfected Cell Line
293T
Plasmid
pCMV-IL12RB1 full-length
Host
Human
Theoretical MW (kDa)
42.4
Interspecies Antigen Sequence
Mouse (47); Rat (47)
Quality Control Testing
Transient overexpression cell lysate was tested with Anti-IL12RB1 antibody (H00003594-B02) by Western Blots.
SDS-PAGE Gel
IL12RB1 transfected lysate.
Western Blot
Lane 1: IL12RB1 transfected lysate ( 42.4 KDa)
Lane 2: Non-transfected lysate.Storage Buffer
1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot
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Gene Info — IL12RB1
Entrez GeneID
3594GeneBank Accession#
BC029121Protein Accession#
AAH29121Gene Name
IL12RB1
Gene Alias
CD212, IL-12R-BETA1, IL12RB, MGC34454
Gene Description
interleukin 12 receptor, beta 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
IL-12 receptor beta component|interleukin-12 receptor beta-1 chain
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