IL12RB1 MaxPab rabbit polyclonal antibody (D01)
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against a full-length human IL12RB1 protein.
Immunogen
IL12RB1 (AAH29121.1, 1 a.a. ~ 381 a.a) full-length human protein.
Sequence
MEPLVTWVVPLLFLFLLSRQGAACRTSECCFQDPPYPDADSGSASGPRDLRCYRISSDRYECSWQYEGPTAGVSHFLRCCLSSGRCCYFAAGSATRLQFSDQAGVSVLYTVTLWVESWARNQTEKSPEVTLQLYNSVKYEPPLGDIKVSKLAGQLRMEWETPDNQVGAEVQFRHRTPSSPWKLGDCGPQDDDTESCLCPLEMNVAQEFQLRRRRLGSQGSSWSKWSSPVCVPPENPPQPQVRFSVEQLGQDGRRRLTLKEQPTQLELPEGCQGLAPGTEVTYRLQLHMLSCPCKAKATRTLHLGKMPYLSGAAYNVAVISSNQFGPGLNQTWHIPADTHTDGMISAHCNLRLPDSRDSPASASRVAGITGICHHTRLILYF
Host
Rabbit
Reactivity
Human
Interspecies Antigen Sequence
Mouse (47); Rat (47)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of IL12RB1 expression in transfected 293T cell line (H00003594-T03) by IL12RB1 MaxPab polyclonal antibody.
Lane 1: IL12RB1 transfected lysate(42.4 KDa).
Lane 2: Non-transfected lysate.
Immunoprecipitation
Immunoprecipitation of IL12RB1 transfected lysate using anti-IL12RB1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead, and immunoblotted with IL12RB1 MaxPab mouse polyclonal antibody (B02) (H00003594-B02). -
Gene Info — IL12RB1
Entrez GeneID
3594GeneBank Accession#
BC029121Protein Accession#
AAH29121.1Gene Name
IL12RB1
Gene Alias
CD212, IL-12R-BETA1, IL12RB, MGC34454
Gene Description
interleukin 12 receptor, beta 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
Other Designations
IL-12 receptor beta component|interleukin-12 receptor beta-1 chain
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Interactome
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Pathway
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Disease
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