IL1A (Human) Recombinant Protein (P01)
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More Files
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Specification
Product Description
Human IL1A full-length ORF ( NP_000566.3, 1 a.a. - 271 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYHVSYGPLHEGCMDQSVSLSISETSKTSKLTFKESMVVVATNGKVLKKRRLSLSQSITDDDLEAIANDSEEEIIKPRSAPFSFLSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQA
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
57
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — IL1A
Entrez GeneID
3552GeneBank Accession#
NM_000575.3Protein Accession#
NP_000566.3Gene Name
IL1A
Gene Alias
IL-1A, IL1, IL1-ALPHA, IL1F1
Gene Description
interleukin 1, alpha
Omim ID
147760Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq
Other Designations
IL1A (IL1F1)|hematopoietin-1|preinterleukin 1 alpha|pro-interleukin-1-alpha
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Interactome
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Pathway
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Disease
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Publication Reference
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Chromatin regulates IL-33 release and extracellular cytokine activity.
Travers J, Rochman M, Miracle CE, Habel JE, Brusilovsky M, Caldwell JM, Rymer JK, Rothenberg ME.
Nature Communications 2018 Aug; 9(1):3244.
Application:Stimulated, Human, HMC-1 mast cells.
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Chromatin regulates IL-33 release and extracellular cytokine activity.
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