CYR61 (Human) Recombinant Protein (P01)
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More Files
- More Functions
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Specification
Product Description
Human CYR61 full-length ORF ( AAH01271.1, 1 a.a. - 381 a.a.) recombinant protein with GST-tag at N-terminal.
Sequence
MSSRIARALALVVTLLHLTRLAPSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICKVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFNDIHKFRD
Host
Wheat Germ (in vitro)
Theoretical MW (kDa)
67.65
Interspecies Antigen Sequence
Mouse (91)
Preparation Method
Purification
Glutathione Sepharose 4 Fast Flow
Quality Control Testing
12.5% SDS-PAGE Stained with Coomassie Blue.
Storage Buffer
50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Storage Instruction
Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Note
Best use within three months from the date of receipt of this protein.
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Applications
Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
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Gene Info — CYR61
Entrez GeneID
3491GeneBank Accession#
BC001271Protein Accession#
AAH01271.1Gene Name
CYR61
Gene Alias
CCN1, GIG1, IGFBP10
Gene Description
cysteine-rich, angiogenic inducer, 61
Omim ID
602369Gene Ontology
HyperlinkGene Summary
CYR61 is a secreted, cysteine-rich, heparin-binding protein encoded by a growth factor-inducible immediate-early gene. Acting as an extracellular, matrix-associated signaling molecule, CYR61 promotes the adhesion of endothelial cells through interaction with integrin and augments growth factor-induced DNA synthesis in the same cell type.[supplied by OMIM
Other Designations
OTTHUMP00000012303|cysteine-rich heparin-binding protein 61|cysteine-rich, anigogenic inducer, 61
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Interactome
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Disease
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Publication Reference
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Sensitive Blood-Based Detection of Asbestos-Associated Diseases Using Cysteine-Rich Angiogenic Inducer 61 as Circulating Protein Biomarker.
Kai Bartkowiak, Swaantje Casjens, Antje Andreas, Lucija Ačkar, Simon A Joosse, Irina Raiko, Thomas Brüning, Maria Geffken, Sven Peine, Georg Johnen, Daniel Gilbert Weber, Klaus Pantel.
Clinical Chemistry 2021 Jan; 67(2):363.
Application:ELISA, Human, As a standard, DM-3, H2452, JL-1, LC-M1, MCF-7, MDA-MB-231 cells, Human plasma.
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CYR61/CCN1 Regulates Sclerostin Levels and Bone Maintenance.
Zhao G, Huang BL, Rigueur D, Wang W, Bhoot C, Charles KR, Baek J, Mohan S, Jiang J, Lyons KM.
Journal of Bone and Mineral Research 2018 Jan; [Epub].
Application:Func, Mouse , Mouse chondro-osseous junctions.
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Cyr61 induces the expression of monocyte chemoattractant protein-1 via the integrin ανβ3, FAK, PI3K/Akt, and NF-κB pathways in retinal vascular endothelial cells.
You JJ, Yang CH, Yang CM, Chen MS.
Cellular Signalling 2014 Jan; 26(1):133.
Application:Stimulated, Recombinant protein.
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Differential Effects of MicroRNAs on Glioblastoma Growth and Migration.
Jeansonne D, Pacifici M, Lassak A, Reiss K, Russo G, Zabaleta J, Peruzzi F.
Genes 2013 Mar; 4(1):46.
Application:WB-Ce, WB-Tr, Human, LN229 cells.
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Simvastatin inhibits Cyr61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of SIRT1/FoxO3a signaling.
Kok SH, Lin LD, Hou KL, Hong CY, Chang CC, Hsiao M, Wang JH, Lai EH, Lin SK.
Arthritis and Rheumatism 2013 Mar; 65(3):639.
Application:ELISA, Human, Rheumatoid arthritis synovial fibroblasts (RASFs).
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Epigallocatechin-3-gallate diminishes cytokine-stimulated Cyr61 expression in human osteoblastic cells: a therapeutic potential for arthritis.
Wu PH, Lin SK, Lee BS, Kok SH, Wang JH, Hou KL, Yang H, Lai EH, Wang JS, Hong CY.
Rheumatology (Oxford, England) 2012 Nov; 51(11):1953.
Application:Func, Human, HBO, U2OS cells.
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Cyr61 is regulated by cAMP-dependent protein kinase with serum levels correlating with prostate cancer aggressiveness.
Terada N, Shiraishi T, Zeng Y, Mooney SM, Yeater DB, Mangold LA, Partin AW, Kulkarni P, Getzenberg RH.
Prostate 2012 Jun; 72(9):966.
Application:ELISA, As a standard.
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Regulation of Cyr61/CCN1 expression by hypoxia through cooperation of c-Jun/AP-1 and HIF-1? in retinal vascular endothelial cells.
You JJ, Yang CM, Chen MS, Yang CH.
Experimental Eye Research 2010 Dec; 91(6):825.
Application:ELISA, As a standard.
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CYR61 regulates BMP-2-dependent osteoblast differentiation through {alpha}v{beta}3 integrin/ILK/ERK pathway.
Su JL, Chiou J, Tang CH, Zhao M, Tsai CH, Chen PS, Chang YW, Chien MS, Peng CY, Hsiao M, Kuo ML, Yen ML.
The Journal of Biological Chemistry 2010 Oct; 285(41):31325.
Application:Func, Mouse, MC3T3-E1, Primary cultured osteoblast cells.
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CCN1 induces a reversible epithelial-mesenchymal transition in gastric epithelial cells.
Chai J, Norng M, Modak C, Reavis KM, Mouazzen W, Pham J.
Laboratory Investigation 2010 Aug; 90(8):1140.
Application:Func, Rat, RGM1 cells.
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Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: A therapeutic benefit for arthritis.
Kok SH, Hou KL, Hong CY, Wang JS, Liang PC, Chang CC, Hsiao M, Yang H, Lai EH, Lin SK.
Arthritis and Rheumatism 2011 Apr; 63(4):1010.
Application:ELISA, Func, Human, U-2 OS cells.
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The pro-angiogenic factor CCN1 enhances the re-endothelialization of biological vascularized matrices in vitro.
Bar A, Dorfman SE, Fischer P, Hilfiker-Kleiner D, Cebotari S, Tudorache I, Suprunov M, Haverich A, Hilfiker A.
Cardiovascular Research 2009 Nov; 85(4):806.
Application:Func, Human, Human cord blood endothelial cells.
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Cysteine-rich 61, a Member of the CCN Family, as a Factor Involved in the Pathogenesis of Proliferative Diabetic Retinopathy.
You JJ, Yang CH, Chen MS, Yang CM.
Investigative Ophthalmology & Visual Science 2009 Jul; 50(7):3447.
Application:Func, ELISA, Monkey, RF/6A cells.
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Involvement of HIF-1alpha -dependent PAI-1 up-regulation in Cyr61/CCN1 induced gastric cancer cell invasion.
Lin MT, Kuo IH, Chen CC, Chu CY, Chen HY, Lin BR, Sureshbabu M, Shih HJ, Kuo ML.
The Journal of Biological Chemistry 2008 Apr; 283(23):15807.
Application:Func, Human, AGS cells.
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Cysteine-Rich 61 (CCN1) Enhances Chemotactic Migration, Transendothelial Cell Migration, and Intravasation by Concomitantly Up-Regulating Chemokine Receptor 1 and 2.
Lin BR, Chang CC, Chen LR, Wu MH, Wang MY, Kuo IH, Chu CY, Chang KJ, Lee PH, Chen WJ, Kuo ML, Lin MT.
Molecular Cancer Research 2007 Nov; 5(11):1111.
Application:Func, WB, Human, AGS cells.
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VEGF-induced upregulation of CCN1 in osteoblasts mediates proangiogenic activities in endothelial cells and promotes fracture healing.
Athanasopoulos AN, Schneider D, Keiper T, Alt V, Pendurthi UR, Liegibel UM, Sommer U, Nawroth PP, Kasperk C, Chavakis T.
The Journal of Biological Chemistry 2007 Jul; 282(37):26746.
Application:Func, Human, Human osteoblasts.
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The angiogenic factor CCN1 promotes adhesion and migration of circulating CD34+ progenitor cells: potential role in angiogenesis and endothelial regeneration.
Grote K, Salguero G, Ballmaier M, Dangers M, Drexler H, Schieffer B.
Blood 2007 Apr; 110(3):877.
Application:Func, Human, HUVEC.
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A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis.
O'Connor RS, Mills ST, Jones KA, Ho SN, Pavlath GK.
Journal of Cell Science 2006 Dec; 120(Pt 1):149.
Application:Func, Mouse, Mouse primary myoblasts.
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Sensitive Blood-Based Detection of Asbestos-Associated Diseases Using Cysteine-Rich Angiogenic Inducer 61 as Circulating Protein Biomarker.
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